Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization …

Sjögren's syndrome (SS) is a chronic autoimmune disease with the pathological hallmark of
lymphoplasmacytic infiltration of exocrine glands-more specifically salivary and lacrimal …

Background All thirteen known mammalian aquaporins have been detected in the eye.
Moreover, aquaporins have been identified as playing essential roles in ocular functions …

Water homeostasis is fundamental for cell survival. Transport of water across cellular
membranes is governed by aquaporins—tetrameric integral membrane channels that are …

High levels of reactive oxygen species such as hydrogen peroxide (H 2 O 2) cause oxidative
stress in the lens and lead to cataractogenesis. The present investigation was undertaken to …

The lens is an important determinant of overall vision quality whose refractive and
transparent properties change throughout life. Alterations to the refractive properties of the …

Aquaporin-5 (AQP5), belonging to the aquaporins (AQPs) family of transmembrane water
channels, facilitates osmotically driven water flux across biological membranes and the …

Purpose The ocular lens contains only two cell types: epithelial cells and fiber cells. The
epithelial cells lining the anterior hemisphere have the capacity to continuously proliferate …

Cataract and presbyopia are the leading cause of vision loss and impaired vision,
respectively, worldwide. Changes in lens biochemistry and physiology with age are …

The pathogenesis of congenital cataract (CC), a major disease associated with blindness in
infants, is complex and diverse. Aquaporin 5 (AQP5) represents an essential membrane …