The increase in the incidence of both hospital-and community-acquired antibiotic-resistant
infections is a major concern to the healthcare community. There have been only two new …

Mycobacterium fortuitum is an emerging human pathogen, characterized by an increase in
prevalence and antibacterial resistance over the years, highlighting the need for the …

The synthesis and properties of 80 short minor groove binders related to distamycin and the
thiazotropsins are described. The design of the compounds was principally predicated upon …

The promise of proteomics to provide a vast library of protein structural data is exciting to
scientists desiring an unprecedented understanding of the relationship between protein …

In 2004, we used NMR to solve the structure of the minor groove binder thiazotropsin A
bound in a 2: 1 complex to the DNA duplex, d (CGACTAGTCG) 2. In this current work, we …

Towards therapeutically viable mimics of host defense cationic peptides (HDCPs) here we
report the design and synthesis of a small library, based on a novel hydrophobic–dipeptide …

'Head-to-head'oligo-N-methylpyrrole peptide dimers linked by a methano [1, 5] diazocin
scaffold are presented in racemic as well as chiral fashion. Their DNA binding activities were …

The synthesis and biological activity of a variety of analogues to the naturally occurring anti-
bacterial and anti-fungal Distamycin A were explored by a number of authors. These …

Several classes of compounds, including heterocyclic polyamides, aryl benzimidazoles,
pyrrolobenzodiazepines, amidino arylfurans and benzofurans, have been found to bind to …

Bioactive small-molecule inhibitors represent a treasure chest for future drugs. In vitro high-
throughput screening is a common approach to identify the small-molecule inhibitors that …