Actin is the main protein used by biological cells to adapt their structure and mechanics to
their needs. Cellular adaptation is made possible by molecular processes that strongly …

During animal development, cell-fate-specific changes in gene expression can modify the
material properties of a tissue and drive tissue morphogenesis. While mechanistic insights …

Contractile forces are the end effectors of cell migration, division, morphogenesis, wound
healing and cancer invasion. Here we report optogenetic tools to upregulate and …

During organismal development, cells undergo complex changes in shape whose causal
relationship to individual morphogenetic processes remains unclear. The modular nature of …

During embryogenesis tissue layers undergo morphogenetic flow rearranging and folding
into specific shapes. While developmental biology has identified key genes and local …

Animal development is characterized by signaling events that occur at precise locations and
times within the embryo, but determining when and where such precision is needed for …

A primary challenge in tissue engineering is to recapitulate both the structural and functional
features of whole tissues and organs. In vivo, patterning of the body plan and constituent …

The synchronous cleavage divisions of early embryogenesis require coordination of the cell-
cycle oscillator, the dynamics of the cytoskeleton, and the cytoplasm. Yet, it remains unclear …

The development of multicellular organisms is controlled by highly dynamic molecular and
cellular processes organized in spatially restricted patterns. Recent advances in …

The Erk mitogen-activated protein kinase plays diverse roles in animal development. Its
widespread reuse raises a conundrum: when a single kinase like Erk is activated, how does …