Human iPSC banking: barriers and opportunities

CY Huang, CL Liu, CY Ting, YT Chiu… - Journal of biomedical …, 2019 - Springer
The introduction of induced pluripotent stem cells (iPSCs) has opened up the potential for
personalized cell therapies and ushered in new opportunities for regenerative medicine …

Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery

VK Singh, M Kalsan, N Kumar, A Saini… - Frontiers in cell and …, 2015 - frontiersin.org
Recent progresses in the field of Induced Pluripotent Stem Cells (iPSCs) have opened up
many gateways for the research in therapeutics. iPSCs are the cells which are …

Preclinical development of a miR-132 inhibitor for heart failure treatment

A Foinquinos, S Batkai, C Genschel, J Viereck… - Nature …, 2020 - nature.com
Despite proven efficacy of pharmacotherapies targeting primarily global neurohormonal
dysregulation, heart failure (HF) is a growing pandemic with increasing burden. Treatments …

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

J Wang, G Xie, M Singh, AT Ghanbarian, T Raskó… - Nature, 2014 - nature.com
Naive embryonic stem cells hold great promise for research and therapeutics as they have
broad and robust developmental potential. While such cells are readily derived from mouse …

Generation of human induced pluripotent stem cells from urine samples

T Zhou, C Benda, S Dunzinger, Y Huang, JC Ho… - Nature protocols, 2012 - nature.com
Human induced pluripotent stem cells (iPSCs) have been generated with varied efficiencies
from multiple tissues. Yet, acquiring donor cells is, in most instances, an invasive procedure …

[HTML][HTML] Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

K Takahashi, S Yamanaka - cell, 2006 - cell.com
Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear
contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about …

Genomic instability of iPSCs: challenges towards their clinical applications

M Yoshihara, Y Hayashizaki, Y Murakawa - Stem cell reviews and reports, 2017 - Springer
Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cells generated directly
from mature cells through the introduction of key transcription factors. iPSCs can be …

Induced pluripotency: history, mechanisms, and applications

M Stadtfeld, K Hochedlinger - Genes & development, 2010 - genesdev.cshlp.org
The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …

Induced pluripotent stem cells—opportunities for disease modelling and drug discovery

M Grskovic, A Javaherian, B Strulovici… - Nature reviews Drug …, 2011 - nature.com
The ability to generate induced pluripotent stem cells (iPSCs) from patients, and an
increasingly refined capacity to differentiate these iPSCs into disease-relevant cell types …

Generation of induced pluripotent stem cells from urine

T Zhou, C Benda, S Duzinger, Y Huang… - Journal of the …, 2011 - journals.lww.com
Forced expression of selected transcription factors can transform somatic cells into
embryonic stem cell (ESC)-like cells, termed induced pluripotent stem cells (iPSCs). There is …