Bilirubin in clinical practice: a review

J Fevery - Liver International, 2008 - Wiley Online Library
Bilirubin is an endogenous compound that can be toxic under certain conditions but, on the
other hand, mild unconjugated hyperbilirubinaemia might protect against cardiovascular …

Paroxysmal nonepileptic events in children and adolescents

P Kotagal, M Costa, E Wyllie, B Wolgamuth - Pediatrics, 2002 - publications.aap.org
Objective. Paroxysmal nonepileptic events (PNEs) are frequently encountered in children
and adolescents; however, there is little information concerning the relative frequency of …

Severe CPT-11 toxicity in patients with Gilbert's syndrome: two case reports

E Wasserman, A Myara, F Lokiec, F Goldwasser… - Annals of …, 1997 - Elsevier
Background CPT-11 is hydrolyzed to its active metabolite SN-38, which is mainly eliminated
through conjugation by hepatic uridine diphosphate glucuronosyl transferases (UGTs) to the …

Bilirubin metabolism and kernicterus

GR Gourley - Advances in pediatrics, 1997 - Elsevier
Neonatal jaundice continues to be a common problem. Kernicterus, although rare, continues
to be a very real concern in both full-term and preterm infants. The diagnosis of kernicterus …

Imbalance between production and conjugation of bilirubin: a fundamental concept in the mechanism of neonatal jaundice

M Kaplan, M Muraca, C Hammerman, FF Rubaltelli… - …, 2002 - publications.aap.org
Objective. The objective of this study was to evaluate the roles of production and conjugation
of bilirubin, individually and in combination, in the mechanism of neonatal jaundice …

Diagnostic methods for neonatal hyperbilirubinemia: benefits, limitations, requirements, and novel developments

CV Hulzebos, L Vitek, CD Coda Zabetta, A Dvořák… - Pediatric …, 2021 - nature.com
Invasive bilirubin measurements remain the gold standard for the diagnosis and treatment of
infants with severe neonatal hyperbilirubinemia. The present paper describes different …

Antioxidant properties of conjugated bilirubin and biliverdin: biologically relevant scavenging of hypochlorous acid

R Stocker, E Peterhans - Free radical research communications, 1989 - Taylor & Francis
Conjugated bilirubin at low micromolar concentrations strongly inhibits the luminol-
enhanced chemilu-minescence response of stimulated human polymorphonuclear …

The analysis of bilirubin in serum

A Westwood - Annals of clinical biochemistry, 1991 - journals.sagepub.com
The most widely used methods for the assay of total bilirubin in serum are based on a
coupling reaction with various diazo dyes in the presence of an accelerating agent. The …

Decreased bilirubin transport in the perfused liver of endotoxemic rats

H Roelofsen, CN Van Der Veere, R Ottenhoff… - Gastroenterology, 1994 - Elsevier
Abstract Background/Aims: Hyperbilirubinemia associated with sepsis is frequently
observed in humans. In this study, an experimental rat model was developed to study …

Glucose-6-phosphate dehydrogenase deficiency and severe neonatal hyperbilirubinemia: a complexity of interactions between genes and environment

M Kaplan, C Hammerman - Seminars in Fetal and Neonatal Medicine, 2010 - Elsevier
Glucose-6-phosphate dehydrogenase deficiency is a commonly occurring genetic condition,
likely to be encountered today in virtually any corner of the globe. Sudden episodes of …