[HTML][HTML] Novel approaches for vaccine development

MS Gebre, LA Brito, LH Tostanoski, DK Edwards… - Cell, 2021 - cell.com
Vaccines are critical tools for maintaining global health. Traditional vaccine technologies
have been used across a wide range of bacterial and viral pathogens, yet there are a …

Nanotechnology for COVID-19: therapeutics and vaccine research

G Chauhan, MJ Madou, S Kalra, V Chopra, D Ghosh… - ACS …, 2020 - ACS Publications
The current global health threat by the novel coronavirus disease 2019 (COVID-19) requires
an urgent deployment of advanced therapeutic options available. The role of …

Crossing the blood-brain barrier with nanoparticles

Y Zhou, Z Peng, ES Seven, RM Leblanc - Journal of controlled release, 2018 - Elsevier
The blood-brain barrier (BBB) is one of the most essential protection mechanisms in the
central nervous system (CNS). It selectively allows individual molecules such as small lipid …

Biocompatible polymer nanoparticles for drug delivery applications in cancer and neurodegenerative disorder therapies

E Calzoni, A Cesaretti, A Polchi, A Di Michele… - Journal of functional …, 2019 - mdpi.com
Polymer nanoparticles (NPs) represent one of the most innovative non-invasive approaches
for drug delivery applications. NPs main objective is to convey the therapeutic molecule be …

COVID-19 vaccine-related thrombosis: a systematic review and exploratory analysis

C Bilotta, G Perrone, V Adelfio, GF Spatola… - Frontiers in …, 2021 - frontiersin.org
Introduction The World Health Organization declared the coronavirus disease 2019 (COVID-
19) pandemic on March 11, 2020. Two vaccine types were developed using two different …

Polymeric nanoparticles: Promising platform for drug delivery

M Khalid, HS El-Sawy - International journal of pharmaceutics, 2017 - Elsevier
Nano medicine had viewed countless breakthroughs in drug delivery implementations. The
main objective of nanotechnology application in delivering and carrying many promising …

Nanoparticle uptake: the phagocyte problem

HH Gustafson, D Holt-Casper, DW Grainger… - Nano today, 2015 - Elsevier
Phagocytes are key cellular participants determining important aspects of host exposure to
nanomaterials, initiating clearance, biodistribution and the tenuous balance between host …

Synthetic nanoparticles for vaccines and immunotherapy

DJ Irvine, MC Hanson, K Rakhra, T Tokatlian - Chemical reviews, 2015 - ACS Publications
The immune system plays a critical role in our health. No other component of human
physiology plays a decisive role in as diverse an array of maladies, from deadly diseases …

NLRP3 inflammasome in neurological diseases, from functions to therapies

L Song, L Pei, S Yao, Y Wu, Y Shang - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …

Current state and challenges in developing oral vaccines

JEV Ramirez, LA Sharpe, NA Peppas - Advanced drug delivery reviews, 2017 - Elsevier
While vaccination remains the most cost effective strategy for disease prevention,
communicable diseases persist as the second leading cause of death worldwide. There is a …