In spite of medical advances, cardiovascular disease remains a significant concern,
imposing a great burden upon the economy and public health of nations by causing the …

Cardiovascular diseases (CVDs) represent a broad spectrum of diseases afflicting the heart
and blood vessels and remain a major cause of death and disability worldwide. CVD …

We recently reported a mouse model of chronic electronic cigarette (e-cig) exposure-
induced cardiovascular pathology, where long-term exposure to e-cig vape (ECV) induces …

Long-term nicotine intake is associated with an increased risk of myocardial damage and
dysfunction. However, it remains unclear whether targeting mitochondrial reactive oxygen …

Melanoma cell metastasis is the main cause of patient death. To develop more effective
strategies for the prevention or treatment of melanoma, we investigated the inhibitory effects …

Prolonged exposure to nicotine accelerates onset and progression of renal diseases in
habitual cigarette smokers. Exposure to nicotine, either via active or passive smoking is …

The cholinergic anti-inflammatory pathway (CAP) is vital for the orchestration of the immune
and inflammatory responses under normal and challenged conditions. Over the past two …

Aim Neurodegeneration is one of the serious adverse effects of stimulant agents such as
nicotine. Minocycline possess established neuroprotective properties. The role of CREB …

Endothelial dysfunction is the early marker and precursor for the development of a series of
vascular disease. Epidemiologic and experimental evidences have suggested that regular …

Increased exposure to nicotine contributes to the development of cardiac dysfunction by
promoting oxidative stress, fibrosis, and inflammation. These deleterious events altogether …