Regulation of protein synthesis in eukaryotes plays a critical role in development,
differentiation, cell cycle progression, cell growth, and apoptosis (Mathews et al. 2000) …

Size is a fundamental attribute impacting cellular design, fitness, and function. Size
homeostasis requires a doubling of cell mass with each division. In yeast, division is delayed …

Rapamycin potently inhibits downstream signaling from the target of rapamycin (TOR)
proteins. These evolutionarily conserved protein kinases coordinate the balance between …

G1-specific transcriptional activation by Cln3/CDK initiates the budding yeast cell cycle. To
identify targets of Cln3/CDK, we analyzed the SBF and MBF transcription factor complexes …

The cyclin-dependent protein kinase (CDK) encoded by CDC28 is the master regulator of
cell division in the budding yeast Saccharomyces cerevisiae. By mechanisms that, for the …

We have analyzed the proteins that are oxidatively damaged when Saccharomyces
cerevisiae cells are exposed to stressing conditions. Carbonyl groups generated by …

Cell division is coupled to cell growth. Since some c-myc target genes are regulators of cell
growth while others function in cell division pathways, c-myc is apparently poised at the …

SUMMARY TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase
that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and …

Glutaredoxins are members of a superfamily of thiol disulfide oxidoreductases involved in
maintaining the redox state of target proteins. In Saccharomyces cerevisiae, two …

Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain
a critical size set by external conditions. However, arguing against deterministic models of …