Targeting angiogenesis in oncology, ophthalmology and beyond

Y Cao, R Langer, N Ferrara - Nature Reviews Drug Discovery, 2023 - nature.com
Angiogenesis is an essential process in normal development and in adult physiology, but
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …

VEGF-targeting drugs for the treatment of retinal neovascularization in diabetic retinopathy

A Arrigo, E Aragona, F Bandello - Annals of medicine, 2022 - Taylor & Francis
Diabetic retinopathy (DR) is the most common microangiopathic complication of diabetes
mellitus, representing a major cause of visual impairment in developed countries …

Aflibercept versus faricimab in the treatment of neovascular age-related macular degeneration and diabetic macular edema: a review

S Liberski, M Wichrowska, J Kocięcki - International Journal of Molecular …, 2022 - mdpi.com
Diabetic macular edema (DME) and neovascular age-related macular degeneration (nAMD)
are common retinal vascular diseases responsible for most blindness in the working-age …

[PDF][PDF] Progress and challenges of anti-VEGF agents and their sustained-release strategies for retinal angiogenesis

M Xu, R Fan, X Fan, Y Shao, X Li - Drug design, development and …, 2023 - Taylor & Francis
Currently, the treatment for ocular neovascular diseases, including diabetic macular edema
(DME) and age-related macular degeneration (AMD), mainly involves repeated intravitreal …

Antibody–drug conjugates and bispecific antibodies targeting cancers: applications of click chemistry

Y Hong, SM Nam, A Moon - Archives of pharmacal research, 2023 - Springer
Engineering approaches using antibody drug conjugates (ADCs) and bispecific antibodies
(bsAbs) are designed to overcome the limitations of conventional chemotherapies and …

Pathologic vs. protective roles of hypoxia-inducible factor 1 in RPE and photoreceptors in wet vs. dry age-related macular degeneration

S Babapoor-Farrokhran, Y Qin… - Proceedings of the …, 2023 - National Acad Sciences
It has previously been reported that antioxidant vitamins can help reduce the risk of vision
loss associated with progression to advanced age-related macular degeneration (AMD), a …

Faricimab for the treatment of diabetic macular edema and neovascular age-related macular degeneration

L Ferro Desideri, CE Traverso, M Nicolò, MR Munk - Pharmaceutics, 2023 - mdpi.com
Nowadays; intravitreal anti-vascular endothelial growth factor (VEGF) drugs are considered
the first-line therapeutic strategy for treating macular exudative diseases; including wet age …

Ten years in the making: application of CrossMab technology for the development of therapeutic bispecific antibodies and antibody fusion proteins

M Surowka, W Schaefer, C Klein - MAbs, 2021 - Taylor & Francis
Bispecific antibodies have recently attracted intense interest. CrossMab technology was
described in 2011 as novel approach enabling correct antibody light-chain association with …

[HTML][HTML] Wet age-related macular degeneration (Wet AMD)

SD Hobbs, K Pierce - StatPearls [Internet], 2022 - ncbi.nlm.nih.gov
Objectives: Describe the risk factors for developing wet age-related macular degeneration.
Outline the typical presentation of a patient with wet age-related macular degeneration …

The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases

L Ferro Desideri, CE Traverso… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Several approaches have been investigated for treating wet age-related
macular degeneration (w-AMD), diabetic macular edema (DME) and retinal vein occlusions …