Hydrocephalus is classically considered as a failure of cerebrospinal fluid (CSF)
homeostasis that results in the active expansion of the cerebral ventricles. Infants with …

Fluid homeostasis is fundamental for brain function with cerebral edema and hydrocephalus
both being major neurological conditions. Fluid movement from blood into brain is one …

The mechanisms underlying post-hemorrhagic hydrocephalus (PHH) development following
subarachnoid hemorrhage (SAH) are not fully understood, which complicates informed …

Regulation of the volume and electrolyte composition of the cerebrospinal fluid (CSF) is vital
for brain development and function. The Na-K-Cl co-transporter NKCC1 in the choroid …

Tumor-associated hydrocephalus (TAH) is a common and lethal complication of brain
metastases. Although other factors beyond mechanical obstructions have been suggested …

Tubulin, one of the most abundant cytoskeletal building blocks, has numerous isotypes in
metazoans encoded by different conserved genes. Whether these distinct isotypes form cell …

Traumatic brain injury (TBI) is a common and often devastating illness, with wide-ranging
public health implications. In addition to the primary injury, victims of TBI are at risk for …

The solute carrier family 12 (SLC12) of cation-chloride cotransporters (CCCs) comprises
potassium chloride cotransporters (KCCs, eg KCC1, KCC2, KCC3, and KCC4)-mediated …

Intraventricular hemorrhage is a potentially life-threatening condition. Approximately 20% of
patients develop posthemorrhagic hydrocephalus with increased ventricular volume and …

Iron physiology is regulated by a complex interplay of extracellular transport systems,
coordinated transcriptional responses, and iron efflux mechanisms. Dysregulation of iron …