Role of RNA modifications in cancer
I Barbieri, T Kouzarides - Nature Reviews Cancer, 2020 - nature.com
Specific chemical modifications of biological molecules are an efficient way of regulating
molecular function, and a plethora of downstream signalling pathways are influenced by the …
molecular function, and a plethora of downstream signalling pathways are influenced by the …
[HTML][HTML] Roles of METTL3 in cancer: mechanisms and therapeutic targeting
C Zeng, W Huang, Y Li, H Weng - Journal of hematology & oncology, 2020 - Springer
Abstract N 6-methyladenosine (m 6 A) is the most abundant mRNA modification and is
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …
[HTML][HTML] How RNA-binding proteins interact with RNA: molecules and mechanisms
M Corley, MC Burns, GW Yeo - Molecular cell, 2020 - cell.com
RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …
The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation
T Liu, Q Wei, J Jin, Q Luo, Y Liu, Y Yang… - Nucleic acids …, 2020 - academic.oup.com
Abstract N 6-Methyladenosine (m6A) is the most abundant RNA modification in mammal
mRNAs and increasing evidence suggests the key roles of m6A in human tumorigenesis …
mRNAs and increasing evidence suggests the key roles of m6A in human tumorigenesis …
[HTML][HTML] Role of m6A RNA methylation in cardiovascular disease
Y Qin, L Li, E Luo, J Hou, G Yan… - International …, 2020 - spandidos-publications.com
Abstract N6‑methyladenosine (m6A) is the most prevalent and abundant type of internal post‑
transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including …
transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including …
[HTML][HTML] METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer
X Chen, MU Xu, X Xu, K Zeng, X Liu, B Pan, C Li… - Molecular cancer, 2020 - Springer
Background Colorectal cancer (CRC) is one of the leading causes of tumor-related death
worldwide, and its main cause of death is distant metastasis. Methyltransferase-like 14 …
worldwide, and its main cause of death is distant metastasis. Methyltransferase-like 14 …
[HTML][HTML] Xist RNA in action: Past, present, and future
A Loda, E Heard - PLoS genetics, 2019 - journals.plos.org
In mammals, dosage compensation of sex chromosomal genes between females (XX) and
males (XY) is achieved through X-chromosome inactivation (XCI). The X-linked X-inactive …
males (XY) is achieved through X-chromosome inactivation (XCI). The X-linked X-inactive …
[HTML][HTML] N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal …
Y Chen, Z Lu, C Qi, C Yu, Y Li, W Huan, R Wang… - Molecular cancer, 2022 - Springer
Background Sunitinib resistance can be classified into primary and secondary resistance.
While accumulating research has indicated several underlying factors contributing to …
While accumulating research has indicated several underlying factors contributing to …
Conserved reduction of m6A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts
R Castro-Hernández, T Berulava… - Proceedings of the …, 2023 - National Acad Sciences
N6-methyladenosine (m6A) regulates mRNA metabolism. While it has been implicated in
the development of the mammalian brain and in cognition, the role of m6A in synaptic …
the development of the mammalian brain and in cognition, the role of m6A in synaptic …
[HTML][HTML] FTO–a common genetic basis for obesity and cancer
N Lan, Y Lu, Y Zhang, S Pu, H Xi, X Nie, J Liu… - Frontiers in …, 2020 - frontiersin.org
In recent years, the prevalence of obesity and cancer have been rising. Since this poses a
serious threat to human health, the relationship between the two has attracted much …
serious threat to human health, the relationship between the two has attracted much …