Exposure to micro-and nanoplastics (MNPs) is inevitable due to their omnipresence in the
environment. A growing body of studies has advanced our understanding of the potential …

The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of
stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we …

We have developed a renewable, scalable and transgene free human blood-brain barrier
model, composed of brain endothelial cells (BECs), generated from human amniotic fluid …

Repair of the endothelial cell barrier after inflammatory injury is essential for tissue fluid
homeostasis and normalizing leukocyte transmigration. However, the mechanisms of …

Intracranial aneurysms (IA) are local dilatations in cerebral arteries that predominantly affect
the circle of Willis. Occurring in approximately 2–5% of adults, these weakened areas are …

Rupture of an intracranial aneurysm leads to aneurysmal subarachnoid hemorrhage, a
severe type of stroke which is, in part, driven by genetic variation. In the past 10 years …

Background Pulmonary arterial hypertension (PAH) is a rare disease characterized by
distinctive changes in pulmonary arterioles that lead to progressive pulmonary arterial …

2 Stroke March 2018 environmental, and stochastic risk factors. 9 A large population-based
heritability study estimated the heritability of SAH to be 41%(95% CI, 23.7%–55.5%) …

Background: Pulmonary arterial hypertension (PAH) is a rare disease characterized by
remodeling of the pulmonary arteries, increased vascular resistance, and right-sided heart …