Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

This review covers some of the recent progress in the field of peptide antibiotics with a focus
on compounds with novel or established mode of action and with demonstrated efficacy in …

Peptide antibiotics are an abundant and synthetically tractable source of molecular diversity,
but they are often cationic and can be cytotoxic, nephrotoxic and/or ototoxic, which has …

Macrocyclisation of proteins and peptides results in a remarkable increase in structural
stability, making cyclic peptides and proteins of great interest in drug discovery—either …

Quantifying phospholipid bilayer–small molecule interactions is vital to the development of
new drug candidates and/or medicinal therapies. However, obtaining these data remains …

Arenicin-3 is an amphipathic β-hairpin antimicrobial peptide that is produced by the lugworm
Arenicola marina. In this study, we have investigated the mechanism of action of arenicin-3 …

One strategy to combat antimicrobial resistance is the discovery of new classes of
antibiotics. Most antibiotics will at some point interact with the bacterial membrane to either …

Multivalent ligands of ion channels have proven to be both very rare and highly valuable in
yielding unique insights into channel structure and pharmacology. Here, we describe a …

NMR is a powerful tool for characterizing intermolecular interactions at atomic resolution.
However, the nature of the complex interactions of membrane-binding proteins makes it …

Chronic pain is a common and often debilitating condition. Existing treatments are either
inefficacious or associated with a wide range of side effects. The progress on developing …