Biosynthesis and function of chondroitin sulfate
T Mikami, H Kitagawa - Biochimica et Biophysica Acta (BBA)-General …, 2013 - Elsevier
Abstract Background Chondroitin sulfate proteoglycans (CSPGs) are principal pericellular
and extracellular components that form regulatory milieu involving numerous biological and …
and extracellular components that form regulatory milieu involving numerous biological and …
New perspectives, opportunities, and challenges in exploring the human protein kinome
LJ Wilson, A Linley, DE Hammond, FE Hood… - Cancer research, 2018 - AACR
The human protein kinome comprises 535 proteins that, with the exception of approximately
50 pseudokinases, control intracellular signaling networks by catalyzing the phosphorylation …
50 pseudokinases, control intracellular signaling networks by catalyzing the phosphorylation …
A single kinase generates the majority of the secreted phosphoproteome
The existence of extracellular phosphoproteins has been acknowledged for over a century.
However, research in this area has been undeveloped largely because the kinases that …
However, research in this area has been undeveloped largely because the kinases that …
Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis
VS Tagliabracci, JL Engel, SE Wiley… - Proceedings of the …, 2014 - National Acad Sciences
The family with sequence similarity 20, member C (Fam20C) has recently been identified as
the Golgi casein kinase. Fam20C phosphorylates secreted proteins on Ser-x-Glu/pSer motifs …
the Golgi casein kinase. Fam20C phosphorylates secreted proteins on Ser-x-Glu/pSer motifs …
Prospects for pharmacological targeting of pseudokinases
Pseudokinases are members of the protein kinase superfamily but signal primarily through
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …
Amelogenesis imperfecta: Next-generation sequencing sheds light on Witkop's classification
A Bloch-Zupan, T Rey, A Jimenez-Armijo… - Frontiers in …, 2023 - frontiersin.org
Amelogenesis imperfecta (AI) is a heterogeneous group of genetic rare diseases disrupting
enamel development (Smith et al., Front Physiol, 2017a, 8, 333). The clinical enamel …
enamel development (Smith et al., Front Physiol, 2017a, 8, 333). The clinical enamel …
The PTH-vitamin d-FGF23 axis
JE Blau, MT Collins - Reviews in Endocrine and Metabolic Disorders, 2015 - Springer
Abstract Fibroblast growth factor 23 (FGF23) has emerged as an important regulator of
phosphate and vitamin D homeostasis. It is important to understand how FGF23 interacts …
phosphate and vitamin D homeostasis. It is important to understand how FGF23 interacts …
An ancestral mycobacterial effector promotes dissemination of infection
JW Saelens, MI Sweeney, G Viswanathan, AM Xet-Mull… - Cell, 2022 - cell.com
The human pathogen Mycobacterium tuberculosis typically causes lung disease but can
also disseminate to other tissues. We identified a M. tuberculosis (Mtb) outbreak presenting …
also disseminate to other tissues. We identified a M. tuberculosis (Mtb) outbreak presenting …
[HTML][HTML] Phosphate metabolism and vitamin D
S Fukumoto - BoneKEy reports, 2014 - ncbi.nlm.nih.gov
Phosphate plays many essential roles in our body. To accomplish these functions, serum
phosphate needs to be maintained in a certain range. Serum phosphate level is regulated …
phosphate needs to be maintained in a certain range. Serum phosphate level is regulated …
[PDF][PDF] Genetic causes of rickets
Rickets is a metabolic bone disease that develops as a result of inadequate mineralization
of growing bone due to disruption of calcium, phosphorus and/or vitamin D metabolism …
of growing bone due to disruption of calcium, phosphorus and/or vitamin D metabolism …