Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

Genetic analyses have shaped much of our understanding of cancer. However, it is
becoming increasingly clear that cancer cells display features of normal tissue organization …

It has long been the dream of biologists to map gene expression at the single-cell level. With
such data one might track heterogeneous cell sub-populations, and infer regulatory …

The genetic, functional or compositional heterogeneity of healthy and diseased tissues
presents major challenges in drug discovery and development. Such heterogeneity hinders …

Persisters are transiently tolerant variants that allow populations to avoid eradication by
antibiotic treatment. Their antibiotic tolerance is non-genetic, not inheritable and results from …

Natural variations in gene expression provide a mechanism for multiple phenotypes to arise
in an isogenic bacterial population. In particular, a sub-group termed persisters show high …

Bacteria form multicellular communities known as biofilms that cause two thirds of all
infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional …

Approximately two decades after the first pioneering analyses, the study of shape asymmetry
with the methods of geometric morphometrics has matured and is a burgeoning field. New …

The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or
'noise', in the levels of their components. Noise, far from just a nuisance, has begun to be …

A central challenge of biology is to understand how individual cells process information and
respond to perturbations. Much of our knowledge is based on ensemble measurements …