Neoplastic growth and many of the hallmark properties of cancer are driven by the disruption
of molecular networks established during the emergence of multicellularity. Regulatory …

Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …

Extensive transcriptional alterations are observed in cancer, many of which activate core
biological processes established in unicellular organisms or suppress differentiation …

It has been acknowledged that source databases recording experimentally supported
human protein-protein interactions (PPIs) exhibit limited overlap. Thus, the reconstruction of …

Network analysis has been a recent focus in biological sciences due to its ability to
synthesize global visualizations of cellular processes and predict functions based on …

The biological function of a protein is usually determined by its physical interaction with
other proteins. Protein–protein interactions (PPIs) are identified through various …

How does central nervous system process information? Current theories are based on two
tenets:(a) information is transmitted by action potentials, the language by which neurons …

Crystal‐cell interactions are a vital step toward kidney stone formation. However, its
mechanisms remained unclear. Here, a protein‐protein interaction (PPI) network analysis of …

Gene regulatory networks (GRNs) consist of different molecular interactions that closely
work together to establish proper gene expression in time and space. Especially in higher …

The main contradiction of multicellularity (MCM) is between the unicellular (UC) and
multicellular (MC) levels. In human interactome we revealed two giant clusters with MC and …