Theranostic Nuclear Medicine with Gallium-68, Lutetium-177, Copper-64/67, Actinium-225, and Lead-212/203 Radionuclides: Focus Review

KA Morgan, SE Rudd, A Noor, PS Donnelly - Chemical Reviews, 2023 - ACS Publications
Molecular changes in malignant tissue can lead to an increase in the expression levels of
various proteins or receptors that can be used to target the disease. In oncology, diagnostic …

Fibrosis imaging: current concepts and future directions

M Baues, A Dasgupta, J Ehling, J Prakash… - Advanced drug delivery …, 2017 - Elsevier
Fibrosis plays an important role in many different pathologies. It results from tissue injury,
chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized …

Harnessing 64Cu/67Cu for a theranostic approach to pretargeted radioimmunotherapy

O Keinänen, K Fung, JM Brennan… - Proceedings of the …, 2020 - National Acad Sciences
Over the past decade, theranostic imaging has emerged as a powerful clinical tool in
oncology for identifying patients likely to respond to targeted therapies and for monitoring …

Engineering poly (ethylene glycol) particles for improved biodistribution

J Cui, R De Rose, K Alt, S Alcantara, BM Paterson… - ACS …, 2015 - ACS Publications
We report the engineering of poly (ethylene glycol)(PEG) hydrogel particles using a
mesoporous silica (MS) templating method via tuning the PEG molecular weight, particle …

[HTML][HTML] Thrombus-targeted theranostic microbubbles: a new technology towards concurrent rapid ultrasound diagnosis and bleeding-free fibrinolytic treatment of …

X Wang, Y Gkanatsas, J Palasubramaniam… - Theranostics, 2016 - ncbi.nlm.nih.gov
Rationale: Myocardial infarction and stroke are leading causes of morbidity/mortality. The
typical underlying pathology is the formation of thrombi/emboli and subsequent vessel …

Peptide-based positron emission tomography probes: Current strategies for synthesis and radiolabelling

M Failla, G Floresta, V Abbate - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
In medical imaging, techniques such as magnetic resonance imaging, contrast-enhanced
computerized tomography, and positron emission tomography (PET) are extensively …

Sortase A‐mediated site‐specific labeling of camelid single‐domain antibody‐fragments: a versatile strategy for multiple molecular imaging modalities

S Massa, N Vikani, C Betti, S Ballet… - Contrast media & …, 2016 - Wiley Online Library
A generic site‐specific conjugation method that generates a homogeneous product is of
utmost importance in tracer development for molecular imaging and therapy. We explored …

Copper radiopharmaceuticals for theranostic applications

A Ahmedova, B Todorov, N Burdzhiev… - European Journal of …, 2018 - Elsevier
The growing advancement in nuclear medicine challenges researchers from several
different fields to integrate imaging and therapeutic modalities in a theranostic …

Poly (ethylene glycol) Cross-Linked Antibody Nanoparticles for Tunable Biointeractions

Y Hu, C Cortez-Jugo, Y Ju, T Zheng, J Zhou… - Chemistry of …, 2023 - ACS Publications
Liver accumulation of nanoparticles is a major challenge in nanoparticle-mediated delivery
as it can reduce the delivery of the nanoparticles to their intended site and lead to liver …

PET radiometals for antibody labeling

E Aluicio‐Sarduy, PA Ellison… - Journal of Labelled …, 2018 - Wiley Online Library
Recent advances in molecular characterization of tumors have made possible the
emergence of new types of cancer therapies where traditional cytotoxic drugs and …