Non-homologous end joining (NHEJ) is the major pathway for the repair of ionizing radiation-
induced DNA double-strand breaks (DSBs) in human cells and is essential for the …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a key member of the
phosphatidylinositol-3 kinase-like (PIKK) family of protein kinases with critical roles in DNA …

There are many large protein complexes involved in transcription in a chromatin context.
However, recent studies on the SAGA coactivator complex are generating new paradigms …

The human nucleosome acetyltransferase of histone H4 (NuA4)/Tat-interactive protein, 60
kilodalton (TIP60) coactivator complex, a fusion of the yeast switch/sucrose nonfermentable …

DNA-dependent protein kinase catalytic subunit DNA-PKcs/PRKDC is the largest
serine/threonine protein kinase of the phosphatidyl inositol 3-kinase-like protein kinase …

Tissue development and homeostasis depend on the balance between growth and terminal
differentiation, but the mechanisms coordinating these processes remain elusive …

Transcription initiation is a major regulatory step in eukaryotic gene expression. It involves
the assembly of general transcription factors and RNA polymerase II into a functional pre …

Abstract Phosphoinositide 3-kinases (PI3K) and phosphoinositide 3-kinase-related protein
kinases (PIKK) are two structurally related families of kinases that play vital roles in cell …

O-GlcNAc transferase (OGT) is the sole enzyme responsible for the post-translational
modification O-GlcNAc on thousands of target nucleocytoplasmic proteins. To date, nine …

MYC, as a well-known oncogene, plays essential roles in promoting tumor occurrence,
development, invasion and metastasis in many kinds of solid tumors and hematologic …