Two major mechanisms of chromosome organization
The spatial organization of chromosomes has long been connected to their polymeric nature
and is believed to be important for their biological functions, including the control of …
and is believed to be important for their biological functions, including the control of …
Mechanisms of enhancer-promoter interactions in higher eukaryotes
O Kyrchanova, P Georgiev - International journal of molecular sciences, 2021 - mdpi.com
In higher eukaryotes, enhancers determine the activation of developmental gene
transcription in specific cell types and stages of embryogenesis. Enhancers transform the …
transcription in specific cell types and stages of embryogenesis. Enhancers transform the …
[HTML][HTML] Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens
N Liscovitch-Brauer, A Montalbano, J Deng… - Nature …, 2021 - nature.com
CRISPR screens have been used to connect genetic perturbations with changes in gene
expression and phenotypes. Here we describe a CRISPR-based, single-cell combinatorial …
expression and phenotypes. Here we describe a CRISPR-based, single-cell combinatorial …
Analysis of Hi-C data using SIP effectively identifies loops in organisms from C. elegans to mammals
Chromatin loops are a major component of 3D nuclear organization, visually apparent as
intense point-to-point interactions in Hi-C maps. Identification of these loops is a critical part …
intense point-to-point interactions in Hi-C maps. Identification of these loops is a critical part …
Transcriptional enhancers and their communication with gene promoters
H Ray-Jones, M Spivakov - Cellular and Molecular Life Sciences, 2021 - Springer
Transcriptional enhancers play a key role in the initiation and maintenance of gene
expression programmes, particularly in metazoa. How these elements control their target …
expression programmes, particularly in metazoa. How these elements control their target …
ZNF143 in chromatin looping and gene regulation
B Ye, G Yang, Y Li, C Zhang, Q Wang, G Yu - Frontiers in genetics, 2020 - frontiersin.org
ZNF143, a human homolog of the transcriptional activator Staf, is a C2H2-type protein
consisting of seven zinc finger domains. As a transcription factor (TF), ZNF143 is sequence …
consisting of seven zinc finger domains. As a transcription factor (TF), ZNF143 is sequence …
LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors
LIN28B is highly expressed in neuroblastoma and promotes tumorigenesis, at least, in part,
through inhibition of let-7 microRNA biogenesis. Here, we report that overexpression of …
through inhibition of let-7 microRNA biogenesis. Here, we report that overexpression of …
The role of ZNF143 overexpression in rat liver cell proliferation
B Ye, W Shen, C Zhang, M Yu, X Ding, M Yin, Y Wang… - BMC genomics, 2022 - Springer
Background Zinc finger protein 143 (ZNF143), a member of the Krüppel C2H2-type zinc
finger protein family, is strongly associated with cell cycle regulation and cancer …
finger protein family, is strongly associated with cell cycle regulation and cancer …
A WIZ/cohesin/CTCF complex anchors DNA loops to define gene expression and cell identity
M Justice, ZM Carico, HC Stefan, JM Dowen - Cell reports, 2020 - cell.com
Chromosome structure is a key regulator of gene expression. CTCF and cohesin play critical
roles in structuring chromosomes by mediating physical interactions between distant …
roles in structuring chromosomes by mediating physical interactions between distant …
[HTML][HTML] CTCF as an example of DNA-binding transcription factors containing clusters of C2H2-type zinc fingers
OG Maksimenko, DV Fursenko, EV Belova… - Acta …, 2021 - ncbi.nlm.nih.gov
In mammals, most of the boundaries of topologically associating domains and all well-
studied insulators are rich in binding sites for the CTCF protein. According to existing …
studied insulators are rich in binding sites for the CTCF protein. According to existing …