Neutrophils are the most abundant immune cells in humans and serve as first responders to
a myriad of host perturbations. Equipped with a plethora of antimicrobial molecules …

Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of
infection, where they fulfill their life-saving antimicrobial functions. While traditionally …

The generation of reactive oxygen species (ROS) plays an important role for the
maintenance of cellular processes and functions in the body. However, the excessive …

Scope Exosomes, small vesicles participating in intercellular communication, have been
extensively studied recently; however, the role of edible plant derived exosomes in …

NADPH oxidase (NOX) isoforms together have multiple functions that are important for
normal physiology and have been implicated in the pathogenesis of a broad range of …

An explosion of new information about mitochondria reveals that their importance extends
well beyond their time-honored function as the “powerhouse of the cell.” In this Perspectives …

ABSTRACT NADPH oxidase is a crucial enzyme in antimicrobial host defense and in
regulating inflammation. Chronic granulomatous disease (CGD) is an inherited disorder of …

Inflammasomes are multiprotein complexes tasked with sensing endogenous or exogenous
inflammatory signals and integrating this signal into a downstream response. Inflammasome …

Neutrophils are armed with both oxidant-dependent and-independent pathways for killing
pathogens. Activation of the phagocyte nicotinamide adenine dinucleotide phosphate …

Significance: The evolution of the lungs and circulatory systems in vertebrates ensured the
availability of molecular oxygen (O2; dioxygen) for aerobic cellular metabolism of internal …