Abstract Treatment of acute myocardial infarction (AMI) has improved significantly in recent
years, but many patients have adverse left ventricular (LV) remodeling, a maladaptive …

Acute myocardial infarction (AMI) and the heart failure that often follows, are major causes of
death and disability worldwide. As such, new therapies are required to limit myocardial …

IL6 is a pleiotropic cytokine that is made in response to perturbations in homeostasis. IL6
becomes elevated in the acute response to host injury and can activate immune cells, direct …

Evidence from both experimental and clinical trials indicates that inflammatory mediators are
of importance in the pathogenesis of chronic heart failure (HF) contributing to cardiac …

Inflammatory response and cytokine elaboration are particularly active after myocardial
infarction and contribute to cardiac remodeling and eventual host outcome. The triggers of …

Background Bone marrow implantation (BMI) was shown to enhance angiogenesis in a rat
ischemic heart model. This preclinical study using a swine model was designed to test the …

In mammalian cells, CAR coreceptors determine efficiency in host cell targeting by
coxsackie and adenoviruses. Coxsackievirus B (CVB) utilizes the complement deflecting …

We tested the hypothesis that the inflammatory cytokines can regulate fibroblast extracellular
matrix metabolism. Neonatal and adult rat cardiac fibroblasts cultures in vitro were exposed …

The incidence of cardiac failure and chronic renal failure is increasing and it has now
become clear that the co-existence of the two problems has an extremely bad prognosis. We …

Persistent inflammatory response has adverse effects on left ventricular (LV) function and
remodeling following acute myocardial infarction. We hypothesized that suppression of …