Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

The cell cycle has the capacity to safeguard the cell's DNA from damage. Thus, cell cycle
arrest can allow tumor cells to investigate their own DNA repair processes. Cancer cells …

Furin is a proprotein convertase that activates different kinds of regulatory proteins, including
SARS-CoV-2 spike protein which contains an additional furin-specific cleavage site. It is …

Objective Breast cancer has become the first highest incidence which surpasses lung
cancer as the most commonly diagnosed cancer, and the second highest mortality among …

The worldwide COVID‑19 pandemic was brought on by a new coronavirus (SARS Cov‑2). A
marker/receptor called Dipeptidyl peptidase 4/CD26 (DPP4/CD26) may be crucial in …

Cyclin-dependent kinase 9 (CDK9) plays a critical role in transcription initiation and is
essential for maintaining gene silencing at heterochromatic loci. Inhibition of CDK9 …

Triple-negative breast cancer (TNBC) is the most difficult breast cancer subtype to treat due
to the lack of targeted therapies. Cancer stem cells (CSCs) are strongly enriched in TNBC …

The human tumor suppressor Ring finger protein 20 (RNF20)-mediated histone H2B
monoubiquitination (H2Bub) is essential for proper chromosome segregation and DNA …

Abstract TMPRSS2 (OMIM: 602060) is a cellular protease involved in many physiological
and pathological processes, and it facilitates entry of viruses such as SARS‐CoV‐2 into host …

Background Nigella sativa (N. sativa) exhibits anti-inflammatory, antioxidant, antidiabetic,
antimetastatic and antinociceptive effects and has been used to treat dozens of diseases …