[HTML][HTML] DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy
R Huang, PK Zhou - Signal transduction and targeted therapy, 2021 - nature.com
Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …
The complex roles of DNA repair pathways, inhibitors, hyperthermia, and contact inhibition in cell cycle halts
The cell cycle has the capacity to safeguard the cell's DNA from damage. Thus, cell cycle
arrest can allow tumor cells to investigate their own DNA repair processes. Cancer cells …
arrest can allow tumor cells to investigate their own DNA repair processes. Cancer cells …
[HTML][HTML] COVID-19 disease and malignant cancers: The impact for the furin gene expression in susceptibility to SARS-CoV-2
D Li, X Liu, L Zhang, J He, X Chen, S Liu… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Furin is a proprotein convertase that activates different kinds of regulatory proteins, including
SARS-CoV-2 spike protein which contains an additional furin-specific cleavage site. It is …
SARS-CoV-2 spike protein which contains an additional furin-specific cleavage site. It is …
[HTML][HTML] RNA-sequencing reveals heat shock 70-kDa protein 6 (HSPA6) as a novel thymoquinone-upregulated gene that inhibits growth, migration, and invasion of …
S Shen, C Wei, J Fu - Frontiers in Oncology, 2021 - frontiersin.org
Objective Breast cancer has become the first highest incidence which surpasses lung
cancer as the most commonly diagnosed cancer, and the second highest mortality among …
cancer as the most commonly diagnosed cancer, and the second highest mortality among …
[HTML][HTML] Effect of DPP4/CD26 expression on SARS‑CoV‑2 susceptibility, immune response, adenosine (derivatives m62A and CD) regulations on patients with …
J Du, J Fu, W Zhang, L Zhang… - International …, 2023 - spandidos-publications.com
The worldwide COVID‑19 pandemic was brought on by a new coronavirus (SARS Cov‑2). A
marker/receptor called Dipeptidyl peptidase 4/CD26 (DPP4/CD26) may be crucial in …
marker/receptor called Dipeptidyl peptidase 4/CD26 (DPP4/CD26) may be crucial in …
RNF20 contributes to epigenetic immunosuppression through CDK9-dependent LSD1 stabilization
Cyclin-dependent kinase 9 (CDK9) plays a critical role in transcription initiation and is
essential for maintaining gene silencing at heterochromatic loci. Inhibition of CDK9 …
essential for maintaining gene silencing at heterochromatic loci. Inhibition of CDK9 …
[HTML][HTML] RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer
E Prokakis, S Jansari, A Boshnakovska, M Wiese… - Cell Death & …, 2023 - nature.com
Triple-negative breast cancer (TNBC) is the most difficult breast cancer subtype to treat due
to the lack of targeted therapies. Cancer stem cells (CSCs) are strongly enriched in TNBC …
to the lack of targeted therapies. Cancer stem cells (CSCs) are strongly enriched in TNBC …
The RPA–RNF20–SNF2H cascade promotes proper chromosome segregation and homologous recombination repair
J Li, J Zhao, X Gan, Y Wang, D Jiang… - Proceedings of the …, 2023 - National Acad Sciences
The human tumor suppressor Ring finger protein 20 (RNF20)-mediated histone H2B
monoubiquitination (H2Bub) is essential for proper chromosome segregation and DNA …
monoubiquitination (H2Bub) is essential for proper chromosome segregation and DNA …
Prostate adenocarcinoma and COVID‐19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS‐CoV‐2
J Cheng, J Zhou, S Fu, J Fu, B Zhou… - Journal of Cellular …, 2021 - Wiley Online Library
Abstract TMPRSS2 (OMIM: 602060) is a cellular protease involved in many physiological
and pathological processes, and it facilitates entry of viruses such as SARS‐CoV‐2 into host …
and pathological processes, and it facilitates entry of viruses such as SARS‐CoV‐2 into host …
PIK3CA hotspot mutations p. H1047R and p. H1047L sensitize breast cancer cells to thymoquinone treatment by regulating the PI3K/Akt1 pathway
J Zhou, S Imani, MD Shasaltaneh, S Liu, T Lu… - Molecular Biology …, 2022 - Springer
Background Nigella sativa (N. sativa) exhibits anti-inflammatory, antioxidant, antidiabetic,
antimetastatic and antinociceptive effects and has been used to treat dozens of diseases …
antimetastatic and antinociceptive effects and has been used to treat dozens of diseases …