Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies

P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

Concise review: mesenchymal stem cells in cardiovascular regeneration: emerging research directions and clinical applications

M Majka, M Sułkowski, B Badyra… - Stem cells translational …, 2017 - academic.oup.com
Experimental and early clinical data suggest that, due to several unique properties,
mesenchymal stem cells (MSCs) may be more effective than other cell types for diseases …

Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium

P Saha, S Sharma, L Korutla, SR Datla… - Science translational …, 2019 - science.org
The stem cell field is hindered by its inability to noninvasively monitor transplanted cells
within the target organ in a repeatable, time-sensitive, and condition-specific manner. We …

Original paper Myocardial regeneration strategy using Wharton's jelly mesenchymal stem cells as an off-the-shelf 'unlimited'therapeutic agent: results from the Acute …

P Musialek, A Mazurek, D Jarocha, L Tekieli… - … Cardiology/Postępy w …, 2015 - termedia.pl
Aim: To evaluate the feasibility and safety of a novel myocardial regeneration strategy using
human WJMSCs as a unique, allogenic but immuno-privileged, off-the-shelf cellular …

Single cell and lineage tracing studies reveal the impact of CD34+ cells on myocardial fibrosis during heart failure

L Du, X Sun, H Gong, T Wang, L Jiang… - Stem Cell Research & …, 2023 - Springer
Background CD34+ cells have been used to treat the patients with heart failure, but the
outcome is variable. It is of great significance to scrutinize the fate and the mechanism of …

Effects of Transendocardial Delivery of Bone Marrow–Derived CD133+ Cells on Left Ventricle Perfusion and Function in Patients With Refractory Angina: Final …

W Wojakowski, T Jadczyk… - Circulation …, 2017 - Am Heart Assoc
Rationale: New therapies for refractory angina are needed. Objective: Assessment of
transendocardial delivery of bone marrow CD133+ cells in patients with refractory angina …

Fluorine-19 labeling of stromal vascular fraction cells for clinical imaging applications

LC Rose, DK Kadayakkara, G Wang… - Stem cells …, 2015 - academic.oup.com
Stromal vascular fraction (SVF) cells are used clinically for various therapeutic targets. The
location and persistence of engrafted SVF cells are important parameters for determining …

Endothelial cell-derived pentraxin 3 limits the vasoreparative therapeutic potential of circulating angiogenic cells

CL O'Neill, J Guduric-Fuchs… - Cardiovascular …, 2016 - academic.oup.com
Aims Circulating angiogenic cells (CACs) promote revascularization of ischaemic tissues
although their underlying mechanism of action and the consequences of delivering varying …

Umbilical cord–derived mesenchymal stromal cells in cardiovascular disease: review of preclinical and clinical data

M Colicchia, DA Jones, AM Beirne, M Hussain… - Cytotherapy, 2019 - Elsevier
The human umbilical cord has recently emerged as an attractive potential source of
mesenchymal stromal cells (MSCs) to be adopted for use in regenerative medicine …

[HTML][HTML] Heterogeneous histomorphology, yet homogeneous vascular smooth muscle cell dedifferentiation, characterize human aneurysm disease

A Busch, E Hartmann, C Grimm, S Ergün… - Journal of vascular …, 2017 - Elsevier
Objective Abdominal aortic aneurysm (AAA) is a frequent, potentially life-threatening,
disease that can only be treated by surgical means such as open surgery or endovascular …