The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila
melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called …

The coordination of growth, DNA replication and division in proliferating cells can be
adequately explained by a 'clock+ checkpoint'model. The clock is an underlying cyclical …

Productive cell proliferation involves efficient and accurate splitting of the dividing cell into
two separate entities. This orderly process reflects coordination of diverse cytological events …

In the cell division cycle of budding yeast, START refers to a set of tightly linked events that
prepare a cell for budding and DNA replication, and FINISH denotes the interrelated events …

Entry into mitosis is driven by the phosphorylation of thousands of substrates, under the
master control of Cdk1. During entry into mitosis, Cdk1, in collaboration with MASTL kinase …

The budding yeast Saccharomyces cerevisiae is a model organism that is commonly used to
investigate control of the eukaryotic cell cycle. Moreover, because of the extensive …

This paper presents the definition, solution and validation of a stochastic model of the
budding yeast cell cycle, based on Stochastic Petri Nets (SPN). A specific family of SPNs is …

The orientation of the mitotic spindle with respect to the polarity axis is crucial for the
accuracy of asymmetric cell division. In budding yeast, a surveillance mechanism called the …

To understand the molecular mechanisms that regulate cell cycle progression in eukaryotes,
a variety of mathematical modeling approaches have been employed, ranging from Boolean …

Exit from mitosis in budding yeast is triggered by activation of the key mitotic phosphatase
Cdc14. At anaphase onset, the protease separase and Zds1 promote the downregulation of …