Hypothalamus and post-traumatic stress disorder: a review

P Raise-Abdullahi, M Meamar, AA Vafaei, M Alizadeh… - Brain sciences, 2023 - mdpi.com
Humans have lived in a dynamic environment fraught with potential dangers for thousands
of years. While fear and stress were crucial for the survival of our ancestors, today, they are …

Neuro-inflammation modulation and post-traumatic brain injury lesions: from bench to bed-side

A Jacquens, EJ Needham, ER Zanier, V Degos… - International journal of …, 2022 - mdpi.com
Head trauma is the most common cause of disability in young adults. Known as a silent
epidemic, it can cause a mosaic of symptoms, whether neurological (sensory–motor …

Neuroimmune mechanisms as novel treatment targets for substance use disorders and associated comorbidities

MD Namba, JM Leyrer-Jackson, EK Nagy… - Frontiers in …, 2021 - frontiersin.org
Recent studies examining the neurobiology of substance abuse have revealed a significant
role of neuroimmune signaling as a mechanism through which drugs of abuse induce …

The relationship between inflammation and post-traumatic stress disorder

Y Sun, Y Qu, J Zhu - Frontiers in Psychiatry, 2021 - frontiersin.org
Background: Stress disorders, such as post-traumatic stress disorder (PTSD), are attracting
much attention. However, the relationship between traumatic stress and inflammation is …

Oxytocin alleviates cognitive and memory impairments by decreasing hippocampal microglial activation and synaptic defects via OXTR/ERK/STAT3 pathway in a …

J Jiang, Y Zou, C Xie, M Yang, Q Tong, M Yuan… - Brain, Behavior, and …, 2023 - Elsevier
Background Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction,
characterized by cognitive and memory impairments closely linked to hippocampal …

Inhibiting Brd4 alleviated PTSD‐like behaviors and fear memory through regulating immediate early genes expression and neuroinflammation in rats

W Wang, R Wang, Z Jiang, H Li, Z Zhu… - Journal of …, 2021 - Wiley Online Library
Post‐traumatic stress disorder (PTSD) is characterized by depression/anxiety and memory
failure, primarily fear memory. According to the reports, neuroinflammation and synaptic …

IL-6 induced by periodontal inflammation causes neuroinflammation and disrupts the blood–brain barrier

D Furutama, S Matsuda, Y Yamawaki, S Hatano… - Brain Sciences, 2020 - mdpi.com
Background: Periodontal disease (PD) is a risk factor for systemic diseases, including
neurodegenerative diseases. The role of the local and systemic inflammation induced by PD …

Oxytocin attenuates microglial activation and restores social and non-social memory in APP/PS1 Alzheimer model mice

MC Selles, JTS Fortuna, YPR de Faria, LD Siqueira… - Iscience, 2023 - cell.com
Alzheimer's disease (AD) is characterized by neurodegeneration, memory loss, and social
withdrawal. Brain inflammation has emerged as a key pathogenic mechanism in AD. We …

Effects of RU486 in treatment of traumatic stress-induced glucocorticoid dysregulation and fear-related abnormalities: Early versus late intervention

CC Lin, PY Cheng, M Hsiao, YP Liu - International journal of molecular …, 2022 - mdpi.com
Central glucocorticoid receptor (GR) activity is enhanced following traumatic events, playing
a key role in the stress-related cognitive abnormalities of posttraumatic stress disorder …

Oxytocin promotes accurate fear discrimination and adaptive defensive behaviors

V Olivera-Pasilio, J Dabrowska - Frontiers in Neuroscience, 2020 - frontiersin.org
The nonapeptide, oxytocin (OT), known for its role in social bonding and attachment
formation, has demonstrated anxiolytic properties in animal models and human studies …