The external globus pallidus (GP e) of the basal ganglia is in a unique and powerful position
to influence processing of motor information by virtue of its widespread projections to all …

The development of methodology to identify specific cell populations and circuits within the
basal ganglia is rapidly transforming our ability to understand the function of this complex …

Brain-derived neurotrophic factor (BDNF) is essential for neuronal differentiation and
survival. We know that BDNF levels decline in the brains of patients with Huntington's …

Objective The goal of this work is to study the changes in white matter integrity in R6/2, a
well-established animal model of Huntington's disease (HD) that are captured by ex vivo …

An electrochemical biosensor for potassium has been developed combining specific
potassium–aptamer binding and RecJf exonuclease mediated signal amplification …

Huntington's disease (HD) is caused by an expanded polyglutamine (polyQ) tract in the
huntingtin (htt) protein. The polyQ expansion increases the propensity of htt to aggregate …

Huntington's disease is a neurodegenerative disorder in which neuronal death leads to
chorea and cognitive decline. Individuals with≥ 40 cytosine–adenine–guanine repeats on …

Huntington disease (HD) is an autosomal dominantly inherited disease that exhibits genetic
anticipation of affected progeny due to expansions of a trinucleotide repeat (TNR) region …

Extrapyramidal movement disorders comprise hypokinetic-rigid and hyperkinetic or mixed
forms, most of them originating from dysfunction of the basal ganglia (BG) and their …

Huntington's disease (HD) is a rare neurodegenerative disorder caused by an expansion of
CAG trinucleotide repeat located in the exon 1 of Huntingtin (HTT) gene in human …