Abstract Ruthenium (II)-arene RAPTA-type compounds have been extensively explored for
their medicinal properties. Herein a comprehensive review of this class of compounds is …

Mass spectrometry (MS) has emerged as an important tool for studying anticancer
metallodrugs in complex biological samples and for characterising their interactions with …

A critical discussion is presented about the possible role of Pt–protein interactions in the
mechanisms of action of platinum anticancer compounds. Although, since 40 years from its …

Low molecular weight and high molecular weight metal ion binders present in blood plasma
are shortly described. The binding of vanadium and ruthenium complexes by these …

Imidazolium [trans-tetrachloro (1 H-imidazole)(S-dimethylsulfoxide) ruthenate (III)](NAMI-A)
and indazolium [trans-tetrachlorobis (1 H-indazole) ruthenate (III)](KP1019) are the most …

A series of six dinuclear gold (III) oxo complexes with bipyridyl ligands, of general formula
[Au2 (N, N) 2 (μ-O) 2][PF6] 2 (Auoxo1− Auoxo6)[where N, N= 2, 2 '-bipyridine (1), 4, 4 '-di-tert …

Metal-based compounds form a promising class of therapeutic agents, whose mechanisms
of action still need to be elucidated, and that are in general prone to undergo extensive …

Multinuclear platinum anticancer complexes are a proven option to overcome resistance of
established anticancer compounds. Transferring this concept to ruthenium complexes led to …

Pt-containing drugs are nowadays essential components in cancer chemotherapy. However,
drug resistance and side effects limit the efficiency of the treatments. In order to improve the …

Protein metalation is a process that determines the formation of adducts upon reaction of
metal compounds with proteins. Protein metalation plays a crucial role in different fields …