[HTML][HTML] Sarcopenia–Molecular mechanisms and open questions
P Wiedmer, T Jung, JP Castro, LCD Pomatto… - Ageing research …, 2021 - Elsevier
Sarcopenia represents a muscle-wasting syndrome characterized by progressive and
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …
Inflammation and skeletal muscle wasting during cachexia
JM Webster, LJAP Kempen, RS Hardy… - Frontiers in …, 2020 - frontiersin.org
Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …
Mitochondrial dysfunction: roles in skeletal muscle atrophy
X Chen, Y Ji, R Liu, X Zhu, K Wang, X Yang… - Journal of Translational …, 2023 - Springer
Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …
health, and damage to mitochondria can lead to a series of pathophysiological changes …
The effect of fasting or calorie restriction on autophagy induction: A review of the literature
Autophagy is a lysosomal degradation process and protective housekeeping mechanism to
eliminate damaged organelles, long-lived misfolded proteins and invading pathogens …
eliminate damaged organelles, long-lived misfolded proteins and invading pathogens …
Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy
G Milan, V Romanello, F Pescatore, A Armani… - Nature …, 2015 - nature.com
Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic
state characterized by enhanced muscle proteolysis and amino acid release to sustain liver …
state characterized by enhanced muscle proteolysis and amino acid release to sustain liver …
Mechanisms regulating skeletal muscle growth and atrophy
Skeletal muscle mass increases during postnatal development through a process of
hypertrophy, ie enlargement of individual muscle fibers, and a similar process may be …
hypertrophy, ie enlargement of individual muscle fibers, and a similar process may be …
[HTML][HTML] Essential role for autophagy in life span extension
F Madeo, A Zimmermann, MC Maiuri… - The Journal of clinical …, 2015 - Am Soc Clin Investig
Life and health span can be prolonged by calorie limitation or by pharmacologic agents that
mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient …
mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient …
Autophagy and aging: Maintaining the proteome through exercise and caloric restriction
KA Escobar, NH Cole, CM Mermier… - Aging cell, 2019 - Wiley Online Library
Accumulation of dysfunctional and damaged cellular proteins and organelles occurs during
aging, resulting in a disruption of cellular homeostasis and progressive degeneration and …
aging, resulting in a disruption of cellular homeostasis and progressive degeneration and …
[HTML][HTML] Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasome
M Sandri - The international journal of biochemistry & cell biology, 2013 - Elsevier
Skeletal muscle adapts its mass as consequence of physical activity, metabolism and
hormones. Catabolic conditions or inactivity induce signaling pathways that regulate the …
hormones. Catabolic conditions or inactivity induce signaling pathways that regulate the …
[HTML][HTML] Sarcopenia in cancer: risking more than muscle loss
Sarcopenia is characterised by progressive and extensive skeletal muscle degeneration
and is associated with functional decline. Sarcopenia has primary and secondary aetiology …
and is associated with functional decline. Sarcopenia has primary and secondary aetiology …