Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy

D Tewari, P Patni, A Bishayee, AN Sah… - Seminars in cancer …, 2022 - Elsevier
Abstract The phosphatidylinositol 3-kinase (PI3K)-Akt and the mammalian target of
rapamycin (mTOR) represent two vital intracellular signaling pathways, which are …

Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment

MA Alzohairy - Evidence‐Based Complementary and …, 2016 - Wiley Online Library
Neem (Azadirachta indica) is a member of the Meliaceae family and its role as health‐
promoting effect is attributed because it is rich source of antioxidant. It has been widely used …

The Akt pathway in oncology therapy and beyond

GM Nitulescu, M Van De Venter… - International …, 2018 - spandidos-publications.com
Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell
death and survival, playing a pivotal role in multiple interconnected cell signaling …

Neem (Azadirachta indica): An indian traditional panacea with modern molecular basis

SC Gupta, S Prasad, AK Tyagi, AB Kunnumakkara… - Phytomedicine, 2017 - Elsevier
Background For centuries, agents derived from natural sources (mother nature), especially
plants have been the primary source of medicine. Neem, also referred to as Azadirachta …

[PDF][PDF] The PI3K/AKT pathway in the pathogenesis of prostate cancer

H Chen, L Zhou, X Wu, R Li, J Wen… - … Biosci (Landmark Ed), 2016 - article.imrpress.com
Despite recent advances in our understanding of the biological behavior of prostate cancer
(PCa), PCa is becoming the most common malignancy in men worldwide. The …

Potential of neem (Azadirachta indica L.) for prevention and treatment of oncologic diseases

SM Patel, KCN Venkata, P Bhattacharyya… - Seminars in cancer …, 2016 - Elsevier
Throughout time, plants have often displayed medicinal properties that have been
underscored. We often derive medicines involved in treating cancer from components in …

Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway

P Elumalai, DN Gunadharini, K Senthilkumar… - Toxicology letters, 2012 - Elsevier
We aimed to investigate the cytotoxic effects of nimbolide, a limonoid present in leaves and
flowers of the neem tree (Azadirachta indica) on human breast cancer cells. The molecular …

Plant-based versus metal-based coagulants in aquaculture wastewater treatment: Effect of mass ratio and settling time

A Ahmad, SRS Abdullah, HA Hasan… - Journal of water process …, 2021 - Elsevier
Azadirachta indica, or Neem, is a natural plant commonly used in medicine and pesticides
due to the useful compounds it contains. This study aimed to determine the performance of …

[PDF][PDF] Pharmacological and therapeutic potential of neem (Azadirachta indica)

A Rahmani, A Almatroudi, F Alrumaihi… - Pharmacognosy …, 2018 - researchgate.net
Azadirachta indica, a member of the Meliaceae family, is commonly known as neem and its
role in disease cure has been documented. Different parts of this tree contain numerous …

Neem components as potential agents for cancer prevention and treatment

F Hao, S Kumar, N Yadav, D Chandra - Biochimica et Biophysica Acta (BBA …, 2014 - Elsevier
Azadirachta indica, also known as neem, is commonly found in many semi-tropical and
tropical countries including India, Pakistan, and Bangladesh. The components extracted …