Tight junction proteins occludin and ZO‐1 as regulators of epithelial proliferation and survival

WT Kuo, MA Odenwald, JR Turner… - Annals of the New York …, 2022 - Wiley Online Library
Epithelial cells are the first line of mucosal defense. In the intestine, a single layer of
epithelial cells must establish a selectively permeable barrier that supports nutrient …

COVID-19, renin-angiotensin system and endothelial dysfunction

R Amraei, N Rahimi - Cells, 2020 - mdpi.com
The newly emergent novel coronavirus disease 2019 (COVID-19) outbreak, which is caused
by SARS-CoV-2 virus, has posed a serious threat to global public health and caused …

Tight junctions as a key for pathogens invasion in intestinal epithelial cells

T Paradis, H Bègue, L Basmaciyan, F Dalle… - International journal of …, 2021 - mdpi.com
Tight junctions play a major role in maintaining the integrity and impermeability of the
intestinal barrier. As such, they act as an ideal target for pathogens to promote their …

Mxra8 is a receptor for multiple arthritogenic alphaviruses

R Zhang, AS Kim, JM Fox, S Nair, K Basore… - Nature, 2018 - nature.com
Arthritogenic alphaviruses comprise a group of enveloped RNA viruses that are transmitted
to humans by mosquitoes and cause debilitating acute and chronic musculoskeletal …

Inflammation and the intestinal barrier: leukocyte–epithelial cell interactions, cell junction remodeling, and mucosal repair

AC Luissint, CA Parkos, A Nusrat - Gastroenterology, 2016 - Elsevier
The intestinal tract is lined by a single layer of columnar epithelial cells that forms a dynamic,
permeable barrier allowing for selective absorption of nutrients, while restricting access to …

Virus–receptor interactions: the key to cellular invasion

MS Maginnis - Journal of molecular biology, 2018 - Elsevier
Virus–receptor interactions play a key regulatory role in viral host range, tissue tropism, and
viral pathogenesis. Viruses utilize elegant strategies to attach to one or multiple receptors …

The sweet spot: defining virus–sialic acid interactions

JE Stencel-Baerenwald, K Reiss, DM Reiter… - Nature Reviews …, 2014 - nature.com
Viral infections are initiated by attachment of the virus to host cell surface receptors,
including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan …

M cells: intelligent engineering of mucosal immune surveillance

A Dillon, DD Lo - Frontiers in immunology, 2019 - frontiersin.org
M cells are specialized intestinal epithelial cells that provide the main machinery for
sampling luminal microbes for mucosal immune surveillance. M cells are usually found in …

The cell biology of receptor-mediated virus entry

J Grove, M Marsh - Journal of Cell Biology, 2011 - rupress.org
The cell imposes multiple barriers to virus entry. However, viruses exploit fundamental
cellular processes to gain entry to cells and deliver their genetic cargo. Virus entry pathways …

Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis

G Bazzoni, E Dejana - Physiological reviews, 2004 - journals.physiology.org
Intercellular junctions mediate adhesion and communication between adjoining endothelial
and epithelial cells. In the endothelium, junctional complexes comprise tight junctions …