Anti-inflammatory and active biological properties of the plant-derived bioactive compounds luteolin and luteolin 7-glucoside

S Caporali, A De Stefano, C Calabrese, A Giovannelli… - Nutrients, 2022 - mdpi.com
Flavonoids are interesting molecules synthetized by plants. They can be found abundantly
in seeds and fruits, determining the color, flavor, and other organoleptic characteristics, as …

Hormesis determines lifespan

EJ Calabrese, M Nascarella, P Pressman… - Ageing Research …, 2024 - Elsevier
This paper addresses how long lifespan can be extended via multiple interventions, such as
dietary supplements [eg, curcumin, resveratrol, sulforaphane, complex phytochemical …

Luteolin: A flavone with myriads of bioactivities and food applications

SP Bangar, P Kajla, V Chaudhary, N Sharma, F Ozogul - Food Bioscience, 2023 - Elsevier
Flavonoids are increasingly applied in foods to promote their functional properties, human
health, and overall wellbeing. Luteolin, a polyphenolic plant flavonoid, is recognized as one …

Environmental hormesis: From cell to ecosystem

EA Erofeeva - Current Opinion in Environmental Science & Health, 2022 - Elsevier
According to the concept of environmental hormesis, hormetic stimulation can be caused by
any low-dose stressors (abiotic, biotic, anthropogenic), including new environmental …

An ultra-sensitive luteolin sensor based on Co-doped nitrogen-containing carbon framework/MoS2− MWCNTs composite for natural sample detection

Y Wang, M Ni, J Chen, C Wang, Y Yang, Y Xie… - Electrochimica …, 2023 - Elsevier
As a common antioxidant and antimicrobial agent in plants, luteolin has a variety of
pharmacological activities and biological effects, the ability to specifically bind proteins and …

Hormesis: Wound healing and keratinocytes

EJ Calabrese, G Dhawan, R Kapoor… - Pharmacological …, 2022 - Elsevier
Hormetic dose responses (ie, a biphasic dose/concentration response characterized by a
low dose stimulation and a high dose inhibition) are shown herein to be commonly reported …

Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular …

M Scuto, S Modafferi, F Rampulla, V Zimbone… - Mechanisms of Ageing …, 2022 - Elsevier
Recent evidence demonstrates that Crocus sativus L.(saffron) counteracts oxidative stress,
mitochondrial dysfunction and neuroinflammation, closely linked to initiation and …

Hormesis: Transforming disciplines that rely on the dose response

EJ Calabrese, E Agathokleous - Iubmb Life, 2022 - Wiley Online Library
This article tells the story of hormesis from its conceptual and experimental origins, its
dismissal by the scientific and medical communities in the first half of the 20th century, and …

Naringin commonly acts via hormesis

EJ Calabrese, P Pressman, AW Hayes… - Science of The Total …, 2023 - Elsevier
The present paper provides the first integrative assessment of the capacity of naringin and
its metabolite, naringenin, to induce hormetic dose responses within a broad range of …

Polyamines and hormesis: making sense of a dose response dichotomy

E Calabrese, AW Hayes, P Pressman, R Kapoor… - Chemico-Biological …, 2023 - Elsevier
The diverse biological effects of polyamines (putrescine, spermidine and spermine) were
reviewed in the context of hormesis in an integrative manner for the first time. The findings …