The toxicological relevance of the micronucleus (MN) test is well defined: it is a multi-target
genotoxic endpoint, assessing not only clastogenic and aneugenic events but also some …

Abstract The Scientific Committee reviewed the current state‐of‐the‐science on genotoxicity
testing and provided a commentary and recommendations on genotoxicity testing strategies …

At the Washington “2nd International Workshop on Genotoxicity Testing”(25–26 March
1999) current methodologies and data for the in vitro micronucleus test were reviewed. As a …

The European Scientific Committee on Cosmetics and Non-Food Products (SCCNFP)
guideline for testing of hair dyes for genotoxic/mutagenic/carcinogenic potential has been …

Los plaguicidas son de los grupos de agentes químicos más ampliamente utilizados por el
hombre, tanto para proteger de organismos nocivos la producción y calidad de las …

The battery of genetic toxicity tests required by most regulatory authorities includes both
bacterial and mammalian cell assays and identifies practically all genotoxic carcinogens …

In the past decade several studies comparing the in vitro chromosome aberration test (CAT)
and the in vitro micronucleus test (MNT) were performed. A high correlation was observed in …

This practical guide presents a road map for safety assessment as an integral part of the
development of new drugs and therapeutics. Helps readers solve scientific, technical, and …

This study, coordinated by the SFTG (French branch of European Environmental Mutagen
Society), included 38 participants from Europe, Japan and America. Clastogens (bleomycin …

The present study investigates leachate hazardous effects on marine biota and human cells,
with the use of a battery of assays, both under in vivo and in vitro conditions. According to …