Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Abstract In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic
review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept …

Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on
humans. We revisit important concepts from the older literature and describe the interaction …

Neurovascular coupling reflects the close temporal and regional linkage between neural
activity and cerebral blood flow. Although providing mechanistic insight, our understanding …

Resistance of large arteries appears to be greater in the cerebral circulation than in other
vascular beds. Large arteries contribute importantly to total cerebral vascular resistance and …

A comparison of the major cerebral arteries between humans and rats shows many
similarities, including anomalies in their general organization, the structure of these vessels …

The pathogenesis of normal-tension glaucoma remains unknown. Because ocular
vasospasm has been proposed as a possible mechanism, we investigated ocular vessel …

The incidence of cardiovascular disease (CVD) is lower in premenopausal women but
increases with age and menopause compared with similarly aged men. Based on the …

Based on the body of evidence implicating ocular blood flow disturbances in the
pathogenesis of glaucoma, there is great interest in the investigation of the effects of …

Flow-mediated dilatation has been described mainly in peripheral conduit arteries. The goal
of this study was to examine mechanisms and functional implications of flow-mediated …