[HTML][HTML] Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers
Rationale: The human ligases (LIG1, LIG3 and LIG4) are essential for the maintenance of
genomic integrity by catalysing the formation of phosphodiester bonds between adjacent …
genomic integrity by catalysing the formation of phosphodiester bonds between adjacent …
Moving the Needle Forward in Genomically-Guided Precision Radiation Treatment
A Tam, BD Mercier, RM Thomas, E Tizpa, IG Wong… - Cancers, 2023 - mdpi.com
Simple Summary Genetic information is seldom incorporated in formulating radiation
treatment recommendations for patients with cancer, even though genetic information is now …
treatment recommendations for patients with cancer, even though genetic information is now …
Traditional Chinese medicine curcumin sensitizes human colon cancer to radiation by altering the expression of DNA repair-related genes
G Yang, J Qiu, D Wang, Y Tao, Y Song… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: The aim of the present study was to investigate the radio-sensitizing
efficacy of curcumin, a traditional Chinese medicine (TCM) on colon cancer cells in vitro and …
efficacy of curcumin, a traditional Chinese medicine (TCM) on colon cancer cells in vitro and …
RAD50 expression is associated with poor clinical outcomes after radiotherapy for resected non–small cell lung cancer
Purpose: Although postoperative radiotherapy is often used to maintain local control after
surgical resection and chemotherapy for locally advanced non–small cell lung cancer …
surgical resection and chemotherapy for locally advanced non–small cell lung cancer …
[HTML][HTML] Androgen-dependent alternative mRNA isoform expression in prostate cancer cells
J Munkley, TM Maia, N Ibarluzea, KE Livermore… - …, 2018 - ncbi.nlm.nih.gov
Background: Androgen steroid hormones are key drivers of prostate cancer. Previous work
has shown that androgens can drive the expression of alternative mRNA isoforms as well as …
has shown that androgens can drive the expression of alternative mRNA isoforms as well as …
Nonhomologous end joining repair pathway molecules as predictive biomarkers for patients with oral squamous cell carcinoma
Purpose: Nonhomologous end-joining (NHEJ) is critical for the repair of either pathologic
double-strand breaks (DSBs) and/or for the repair of physiologic DSBs created during …
double-strand breaks (DSBs) and/or for the repair of physiologic DSBs created during …
Identification of LIG1 and LIG3 as prognostic biomarkers in breast cancer
L Sun, X Liu, S Song, L Feng, C Shi, Z Sun, B Chen… - Open …, 2021 - degruyter.com
DNA ligase (LIG) plays a key role in connecting the 3′-OH end of a DNA strand to the 5′-P
end of another DNA strand, resulting in the formation of a phosphodiester bond. It has been …
end of another DNA strand, resulting in the formation of a phosphodiester bond. It has been …
[PDF][PDF] Androgen-dependent alternative mRNA isoform expression in
J Munkley, TM Maia, N Ibarluzea… - cancer cells [version 1; …, 2018 - academia.edu
Background: Previous work has shown that androgens can drive the expression of
alternative mRNA isoforms as well as transcriptional changes in prostate cancer cells. Yet to …
alternative mRNA isoforms as well as transcriptional changes in prostate cancer cells. Yet to …