Actinic keratoses are dysplastic proliferations of keratinocytes with potential for malignant
transformation. Clinically, actinic keratoses present as macules, papules, or hyperkeratotic …

Advances in genotyping technology have, over the past decade, enabled the focused
search for common genetic variation associated with human diseases and traits. With the …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Background Actinic keratosis is the most frequent premalignant skin disease in the white
population. In current guidelines, no clear recommendations are made about which …

Many modern human genomes retain DNA inherited from interbreeding with archaic
hominins, such as Neandertals, yet the influence of this admixture on human traits is largely …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Field cancerization was first described in 1953 when pathologic atypia was identified in
clinically normal tissue surrounding oropharyngeal carcinomas. The discovery of mutated …

Actinic keratoses (AKs) are common, with prevalence in the USA estimated at almost 40
million in 2004 and annual costs of> $1 billion (USD). However, there is no universally …

NICE has renewed accreditation of the process used by the British Association of
Dermatologists to produce clinical guidelines. The renewed accreditation is valid until 31 …