Metastasis remains the major driver of mortality in patients with cancer. Our growing body of
knowledge regarding this process provides the basis for the development of molecularly …

Background: Metastasis is the primary cause of death in most human cancers, and
understanding the molecular mechanisms underpinning this multistep process is …

Methylcytosine (m5C) is a posttranscriptional RNA modification participating in many critical
bioprocesses, but its functions in human cancer remain unclear. Here, by detecting the …

Matrix metalloproteinases (MMPs) have been shown to be key players in both extracellular
matrix remodeling and cell migration during cancer metastasis. MMP-14, a membrane …

Src homology 2 (SH2) domains are 100 amino acid modular units, which recognize and
bind to tyrosyl-phosphorylated peptide sequences on their target proteins, and thereby …

In this study we have identified a functional role for miR-29a in cancer cell invasion and
proliferation. MiRNA expression profiling of human NSCLC cell lines indicated that miR-29a …

Background The erythroblastosis virus E26 transforming sequences (ETS) family of
transcription factors consists of a highly conserved group of genes that play important roles …

Breast cancer is among the most commonly diagnosed cancer types in women worldwide
and is the second leading cause of cancer-related disease in the USA. SH2 domains recruit …

Under normal physiological conditions, the hepatocyte growth factor (HGF) and its receptor,
the MET transmembrane tyrosine kinase (cMET), are involved in embryogenesis …

Renal cell carcinoma (RCC), the most common form of kidney cancer, accounts for 3% of all
adult malignancies and its incidence has significantly increased over the last 20 years. RCC …