Type 2 inflammation in eosinophilic esophagitis: from pathophysiology to therapeutic targets

F Racca, G Pellegatta, G Cataldo, E Vespa… - Frontiers in …, 2022 - frontiersin.org
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus
characterized clinically by symptoms related to esophageal dysfunction and histologically by …

Mechanistic insights into eosinophilic esophagitis: therapies targeting pathophysiological mechanisms

S Massironi, G Mulinacci, C Gallo, A Elvevi, S Danese… - Cells, 2023 - mdpi.com
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized by
eosinophilic infiltration of the esophagus. It arises from a complex interplay of genetic …

[HTML][HTML] Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis

JD Sherrill, K Kc, D Wu, Z Djukic, JM Caldwell… - Mucosal …, 2014 - Elsevier
The desmosomal cadherin desmoglein-1 (DSG1) is an essential intercellular adhesion
molecule that is altered in various human cutaneous disorders; however, its regulation and …

IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization

Z Castano, BP San Juan, A Spiegel, A Pant… - Nature cell …, 2018 - nature.com
Lack of insight into mechanisms governing breast cancer metastasis has precluded the
development of curative therapies. Metastasis-initiating cancer cells (MICs) are uniquely …

Inflammation-associated microbiota in pediatric eosinophilic esophagitis

AJ Benitez, C Hoffmann, AB Muir, KK Dods, JM Spergel… - Microbiome, 2015 - Springer
Abstract Background Eosinophilic esophagitis (EoE) is an allergic disorder characterized by
eosinophil-predominant esophageal inflammation, which can be ameliorated by food …

The prevalence of eosinophilic esophagitis in pediatric patients with IgE-mediated food allergy

DA Hill, JW Dudley, JM Spergel - The Journal of Allergy and Clinical …, 2017 - Elsevier
Background Eosinophilic esophagitis (EoE) is an allergic inflammatory disease that is
triggered by food allergens and characterized by progressive esophageal dysfunction …

Breaking down the complex pathophysiology of eosinophilic esophagitis

B Underwood, TD Troutman, JT Schwartz - Annals of Allergy, Asthma & …, 2023 - Elsevier
Eosinophilic esophagitis (EoE) is a chronic and progressive immune-mediated disease of
the esophagus associated with antigen-driven type 2 inflammation and symptoms of …

[HTML][HTML] The esophageal organoid system reveals functional interplay between notch and cytokines in reactive epithelial changes

Y Kasagi, PM Chandramouleeswaran… - Cellular and molecular …, 2018 - Elsevier
Background & Aims Aberrations in the esophageal proliferation-differentiation gradient are
histologic hallmarks in eosinophilic esophagitis (EoE) and gastroesophageal reflux disease …

Eosinophilic esophagitis and gastroenteritis

A Cianferoni, JM Spergel - Current Allergy and Asthma Reports, 2015 - Springer
Eosinophilic gastrointestinal disease (EGID) can be classified as eosinophilic esophagitis
(EoE) when the eosinophilia is limited to the esophagus or as eosinophilic gastritis (EG) if it …

Eosinophilic esophagitis: a comprehensive review

A Cianferoni, J Spergel - Clinical reviews in allergy & immunology, 2016 - Springer
Eosinophilic esophagitis (EoE) is an emerging chronic atopic clinical-pathologic disease
with an estimated prevalence of 1/1000 similar to the one of Crohn's diseases. Usually, EoE …