The goal of this review is to highlight the wide range of biological activities displayed by
purines, with particular emphasis on new purine-based agents which find potential …

The term Interactome describes the set of all molecular interactions in cells, especially in the
context of protein-protein interactions. These interactions are crucial for most cellular …

Abstract A series of [1, 2, 3] triazolo [4, 5-d] pyrimidine derivatives bearing a hydrazone
moiety were designed, synthesized and evaluated for their antiproliferative activity against …

In order to find novel anti-tumor compounds a series of novel [1, 2, 4] triazolo [1, 5-a]
pyrimidine derivatives has been designed and synthesized. The structures of all the …

The aminobenzamide is selective to class I histone deacetylases (HDACs) and displays
unique tight-binding/slow-off HDAC-binding mechanism. Herein, we report a series of 9 …

In our research on novel anticancer agents, a series of N 6‐hydrazone purine derivatives
were designed and synthesized by analysis of a pharmacophore model for ATP‐competitive …

Local anesthetics are one of the most widely used drug classes in clinical practice. Like
many other biological molecules, their properties are altered depending on their protonation …

A set of novel pyridine-annulated analogs of purinones, adenines and their oxo/thio
congeners, xanthines, guanines, and purine-2, 4-diamines as potential anticancer agents …

A series of new 4β-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives were
synthesized and evaluated, together with some previously prepared ones, for their cytotoxic …

Mercaptopurine and its derivatives are used in the treatment of leukemia. To estimate their
lipophilicity, a simple and novel thin layer chromatography method was developed. The …