Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative primarily affecting
motor neurons, leading to disability and neuronal death, and ATP-Binding Cassette (ABC) …

ABSTRACT Elabela (ELA), Apela or Toddler peptide is a hormone peptide belonging to the
adipokine group and a component of apelinergic system, discovered in 2013-2014. Given its …

ELABELA, an early endogenous ligand for the G protein-coupled receptor APJ (apelin
peptide jejunum, apelin receptor), has been known as an important regulator in …

Lifestyle changes have made metabolic disorders as one of the major threats to life. Growing
evidence demonstrates that obesity and diabetes disrupt the reproductive system by …

Sarcopenia involves a progressive loss of skeletal muscle force, quality and mass during
ageing, which results in increased inability and death; however, no cure has been …

Acute kidney injury (AKI) has emerged as a global health crisis, surpassing mortality rates
associated with several cancers and heart failure. The lack of effective therapies, coupled …

Glioblastoma multiforme (GBM) is one of the most common and lethal forms of brain cancer,
carrying a very poor prognosis (median survival of~ 15 months post-diagnosis). Treatment …

Neuroinflammation is considered to be one of the driving factors in Parkinson's disease
(PD). This study was conducted using neuronal and glial cell cultures differentiated from …

Alzheimer's disease imposes an increasing burden on aging Western societies. The
disorder most frequently appears in its sporadic form, which can be caused by …

Background. Peptidergic GPCR systems are broadly distributed in the human body and
regulate numerous physiological processes by activating complex networks of intracellular …