A structural view of SARS-CoV-2 RNA replication machinery: RNA synthesis, proofreading and final capping
The current coronavirus disease-2019 (COVID-19) pandemic is due to the novel coronavirus
SARS-CoV-2. The scientific community has mounted a strong response by accelerating …
SARS-CoV-2. The scientific community has mounted a strong response by accelerating …
Continuous and discontinuous RNA synthesis in coronaviruses
I Sola, F Almazán, S Zúñiga… - Annual review of …, 2015 - annualreviews.org
Replication of the coronavirus genome requires continuous RNA synthesis, whereas
transcription is a discontinuous process unique among RNA viruses. Transcription includes …
transcription is a discontinuous process unique among RNA viruses. Transcription includes …
The coronavirus proofreading exoribonuclease mediates extensive viral recombination
J Gribble, LJ Stevens, ML Agostini… - PLoS …, 2021 - journals.plos.org
Recombination is proposed to be critical for coronavirus (CoV) diversity and emergence of
SARS-CoV-2 and other zoonotic CoVs. While RNA recombination is required during normal …
SARS-CoV-2 and other zoonotic CoVs. While RNA recombination is required during normal …
Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy
The current pandemic situation caused by the Betacoronavirus SARS-CoV-2 (SCoV2)
highlights the need for coordinated research to combat COVID-19. A particularly important …
highlights the need for coordinated research to combat COVID-19. A particularly important …
Replication and single-cycle delivery of SARS-CoV-2 replicons
Molecular virology tools are critical for basic studies of the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and for developing new therapeutics. Experimental …
syndrome coronavirus 2 (SARS-CoV-2) and for developing new therapeutics. Experimental …
PEDV: insights and advances into types, function, structure, and receptor recognition
F Lin, H Zhang, L Li, Y Yang, X Zou, J Chen, X Tang - Viruses, 2022 - mdpi.com
Porcine epidemic diarrhea virus (PEDV) has been endemic in most parts of the world since
its emergence in the 1970s. It infects the small intestine and intestinal villous cells, spreads …
its emergence in the 1970s. It infects the small intestine and intestinal villous cells, spreads …
[HTML][HTML] Nidovirus RNA polymerases: complex enzymes handling exceptional RNA genomes
CC Posthuma, AJW Te Velthuis, EJ Snijder - Virus research, 2017 - Elsevier
Coronaviruses and arteriviruses are distantly related human and animal pathogens that
belong to the order Nidovirales. Nidoviruses are characterized by their polycistronic plus …
belong to the order Nidovirales. Nidoviruses are characterized by their polycistronic plus …
The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity
Summary Type I interferons (IFN-I) are essential to establish antiviral innate immunity.
Unanchored (or free) polyubiquitin (poly-Ub) has been shown to regulate IFN-I responses …
Unanchored (or free) polyubiquitin (poly-Ub) has been shown to regulate IFN-I responses …
[HTML][HTML] Structural and functional conservation of cis-acting RNA elements in coronavirus 5'-terminal genome regions
R Madhugiri, N Karl, D Petersen, K Lamkiewicz… - Virology, 2018 - Elsevier
Abstract Structure predictions suggest a partial conservation of RNA structure elements in
coronavirus terminal genome regions. Here, we determined the structures of stem-loops …
coronavirus terminal genome regions. Here, we determined the structures of stem-loops …
Generation and functional analysis of defective viral genomes during SARS-CoV-2 infection
Defective viral genomes (DVGs) have been identified in many RNA viruses as a major factor
influencing antiviral immune response and viral pathogenesis. However, the generation and …
influencing antiviral immune response and viral pathogenesis. However, the generation and …