Clinical epigenetics: seizing opportunities for translation
M Berdasco, M Esteller - Nature Reviews Genetics, 2019 - nature.com
Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …
[HTML][HTML] DNA methylation biomarkers in aging and age-related diseases
Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …
alterations in aging and age-related disease. It is currently well established that DNA …
DNA methylation and regulation of gene expression: Guardian of our health
GA Dhar, S Saha, P Mitra, R Nag Chaudhuri - The Nucleus, 2021 - Springer
One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …
The cholinergic system, the adrenergic system and the neuropathology of Alzheimer's disease
RA Bekdash - International Journal of Molecular Sciences, 2021 - mdpi.com
Neurodegenerative diseases are a major public health problem worldwide with a wide
spectrum of symptoms and physiological effects. It has been long reported that the …
spectrum of symptoms and physiological effects. It has been long reported that the …
Current concepts of neurodegenerative mechanisms in Alzheimer's disease
KB Magalingam, A Radhakrishnan… - BioMed research …, 2018 - Wiley Online Library
Neurodegenerative diseases are hereditary or sporadic conditions that result in the
progressive loss of the structure and function of neurons as well as neuronal death …
progressive loss of the structure and function of neurons as well as neuronal death …
[HTML][HTML] The epigenetics of Alzheimer's disease: factors and therapeutic implications
X Liu, B Jiao, L Shen - Frontiers in genetics, 2018 - frontiersin.org
Alzheimer's disease (AD) is a well-known neurodegenerative disorder that imposes a great
burden on the world. The mechanisms of AD are not yet fully understood. Current insight into …
burden on the world. The mechanisms of AD are not yet fully understood. Current insight into …
Alzheimer's disease-associated (hydroxy) methylomic changes in the brain and blood
R Lardenoije, JAY Roubroeks, E Pishva, M Leber… - Clinical …, 2019 - Springer
Abstract Background Late-onset Alzheimer's disease (AD) is a complex multifactorial
affliction, the pathogenesis of which is thought to involve gene-environment interactions that …
affliction, the pathogenesis of which is thought to involve gene-environment interactions that …
Epigenetics in Alzheimer's disease: perspective of DNA methylation
Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …
understood, but over the past years, the involvement of epigenetic mechanisms in the …
Frailty and cognitive decline
D de Morais Fabrício, MHN Chagas, BS Diniz - Translational Research, 2020 - Elsevier
Frailty and cognitive impairment are among the 2 most common geriatric syndromes. Their
presence poses major risks to the elderly including greater disability, reduced quality of life …
presence poses major risks to the elderly including greater disability, reduced quality of life …
Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines and neurogenesis–What do we need to know?
J Herbert, PJ Lucassen - Frontiers in neuroendocrinology, 2016 - Elsevier
Depression (MDD) is prodromal to, and a component of, Alzheimer's disease (AD): it may
also be a trigger for incipient AD. MDD is not a unitary disorder, so there may be particular …
also be a trigger for incipient AD. MDD is not a unitary disorder, so there may be particular …