Radiation‐induced fibrosis (RIF) develops months to years after initial radiation exposure.
RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant …

Cardiovascular diseases are one of the leading causes of death worldwide and cardiac
fibrosis is a common pathological process for cardiac remodeling in cardiovascular …

Curcumin, a polyphenolic compound derived from turmeric, protects against myocardial
injury by alleviating oxidative stress, inflammation, apoptosis, and fibrosis. However, the role …

Berberine (BBR) exerts potential protective effect against myocardial ischemia/reperfusion
(MI/R) injury. Activation of silent information regulator 1 (SIRT1) signaling attenuates MI/R …

Diabetes mellitus (DM) is one of the principal manifestations of metabolic syndrome and its
prevalence with modern lifestyle is increasing incessantly. Chronic hyperglycemia can …

Background: Sirtuin1 is an epigenetic enzyme involved in histone and nonhistone protein
deacetylation. It acts primarily as a metabolic sensor, which responses to changing energy …

This study examined the cardiac anti-cardiomyopathy (DC) protective effect of urolithin A in
streptozotocin (STZ)-treated rats and investigated if this protection involves activation of …

This study investigated if kaempferol could attenuate the oxidative, inflammatory, and fibrotic
damage of the left ventricles (LVs) in streptozotocin (STZ)-diabetic rats by modulating silent …

In cardiac fibrosis, following an injury or a stress, non-functional fibrotic tissue substitutes
normal myocardium, thus leading to progressive heart failure. Activated fibroblasts are …

This study investigated the protective effect of ellagic acid (EA) against diabetic
cardiomyopathy (DC) in streptozotocin (STZ)-treated rats and examined if the mechanism of …