Zebrafish models of cardiac disease: From fortuitous mutants to precision medicine

JM González-Rosa - Circulation research, 2022 - Am Heart Assoc
Heart disease is the leading cause of death worldwide. Despite decades of research, most
heart pathologies have limited treatments, and often the only curative approach is heart …

Industrial lab-on-a-chip: Design, applications and scale-up for drug discovery and delivery

GT Vladisavljević, N Khalid, MA Neves… - Advanced drug delivery …, 2013 - Elsevier
Microfluidics is an emerging and promising interdisciplinary technology which offers
powerful platforms for precise production of novel functional materials (eg, emulsion …

Microinjection in biomedical applications: An effortless autonomous omnidirectional microinjection system

S Zhuang, D Lei, X Yu, M Tong, W Lin… - IEEE Industrial …, 2023 - ieeexplore.ieee.org
Thanks to the advancements in micro-and nanomechatronics techniques, the capability to
inject foreign materials into target locations inside biosamples has become increasingly …

Advances in microfluidic devices made from thermoplastics used in cell biology and analyses

E Gencturk, S Mutlu, KO Ulgen - Biomicrofluidics, 2017 - pubs.aip.org
Silicon and glass were the main fabrication materials of microfluidic devices, however,
plastics are on the rise in the past few years. Thermoplastic materials have recently been …

[HTML][HTML] An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination

JJ Early, KLH Marshall-Phelps, JM Williamson, M Swire… - elife, 2018 - elifesciences.org
Myelinating oligodendrocytes are essential for central nervous system (CNS) formation and
function. Their disruption is implicated in numerous neurodevelopmental, neuropsychiatric …

[HTML][HTML] Engineering approaches to illuminating brain structure and dynamics

K Deisseroth, MJ Schnitzer - Neuron, 2013 - cell.com
Historical milestones in neuroscience have come in diverse forms, ranging from the
resolution of specific biological mysteries via creative experimentation to broad …

Zebrafish model in drug safety assessment

J Kanungo, E Cuevas, SF Ali… - Current pharmaceutical …, 2014 - ingentaconnect.com
Over the past decade, zebrafish are being increasingly used in assessing the effects of
chemical compounds. Especially, the embryos and larvae, due to their microscopically small …

Zebrafish in vivo models of cancer and metastasis

KR Astell, D Sieger - Cold Spring Harbor …, 2020 - perspectivesinmedicine.cshlp.org
Metastasis, the dispersal of cancer cells from a primary tumor to secondary sites within the
body, is the leading cause of cancer-related death. Animal models have been an …

[HTML][HTML] Robotic injection of zebrafish embryos for high-throughput screening in disease models

HP Spaink, C Cui, MI Wiweger, HJ Jansen… - Methods, 2013 - Elsevier
The increasing use of zebrafish larvae for biomedical research applications is resulting in
versatile models for a variety of human diseases. These models exploit the optical …

Imaging technologies for microfluidic biochips

J Han, U Kang, EY Moon, H Yoo, B Gweon - BioChip Journal, 2022 - Springer
With the growing interest in biochips, numerous efforts have been made to recapitulate a
more reliable and physiologically relevant environment within chips, resulting in significant …