Creutzfeldt–Jakob disease (CJD) is a rapidly progressive, fatal and transmissible
neurodegenerative disease associated with the accumulation of misfolded prion protein in …

Prion diseases are progressive, incurable and fatal neurodegenerative conditions. The term
'prion'was first nominated to express the revolutionary concept that a protein could be …

Amyloid fibrils are protein homopolymers that adopt diverse cross-β conformations. Some
amyloid fibrils are associated with the pathogenesis of devastating neurodegenerative …

Prion diseases share common clinical and pathological characteristics such as spongiform
neuronal degeneration and deposition of an abnormal form of a host-derived protein, termed …

Creutzfeldt-Jakob disease (CJD) is a fatal disease presenting with rapidly progressive
dementia, and most patients die within a year of clinical onset. CJD poses a potential risk of …

Most neurodegenerative diseases such as Alzheimer's disease, type 2 diabetes, Parkinson's
disease, etc. are caused by inclusions and plaques containing misfolded protein …

The prototype of transmissible neurodegenerative proteinopathies is prion diseases,
characterized by aggregation of abnormally folded conformers of the native prion protein. A …

The human prion diseases comprise Creutzfeldt–Jakob disease, variably protease-sensitive
prionopathy, Gerstmann–Sträussler–Scheinker disease, fatal familial insomnia, and kuru …

Transmissible spongiform encephalopathies (TSEs) or prion diseases of animals notably
include scrapie in small ruminants, chronic wasting disease (CWD) in cervids and classical …

Prion diseases are progressive neurodegenerative disorders affecting humans and other
mammalian species. The term prion, originally put forward to propose the concept that a …