The importance of glycans of viral and host proteins in enveloped virus infection

Y Li, D Liu, Y Wang, W Su, G Liu, W Dong - Frontiers in Immunology, 2021 - frontiersin.org
Animal viruses are parasites of animal cells that have characteristics such as heredity and
replication. Viruses can be divided into non-enveloped and enveloped viruses if a lipid …

HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation

MA Checkley, BG Luttge, EO Freed - Journal of molecular biology, 2011 - Elsevier
The HIV-1 envelope (Env) glycoproteins play an essential role in the virus replication cycle
by mediating the fusion between viral and cellular membranes during the entry process. The …

Trimeric HIV-1-Env structures define glycan shields from clades A, B, and G

GBE Stewart-Jones, C Soto, T Lemmin, GY Chuang… - Cell, 2016 - cell.com
Summary The HIV-1-envelope (Env) trimer is covered by a glycan shield of∼ 90 N-linked
oligosaccharides, which comprises roughly half its mass and is a key component of HIV …

The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens

R Wyatt, J Sodroski - Science, 1998 - science.org
The human immunodeficiency virus–type 1 (HIV-1) envelope glycoproteins interact with
receptors on the target cell and mediate virus entry by fusing the viral and cell membranes …

Isolation of a new human retrovirus from West African patients with AIDS

F Clavel, D Guétard, F Brun-Vézinet, S Chamaret… - Science, 1986 - science.org
The etiological agent of AIDS, LAV/HTLV-III, is common in Central Africa but is not endemic
in other areas of that continent. A novel human retrovirus, distinct from LAV/HTLV-III, has …

Atomic structure of the ectodomain from HIV-1 gp41

W Weissenhorn, A Dessen, SC Harrison, JJ Skehel… - Nature, 1997 - nature.com
Fusion of viral and cellular membranes by the envelope glyco-protein gp120/gp41 effects
entry of HIV-1 into the cell. The precursor, gp160, is cleaved post-translationally into gp120 …

[HTML][HTML] Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus …

CK Leonard, MW Spellman, L Riddle, RJ Harris… - Journal of Biological …, 1990 - Elsevier
This report describes the structural characterization of the recombinant envelope
glycoprotein (rgp120) of human immunodeficiency virus type 1 produced by expression in …

Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling

VN Uversky, CJ Oldfield… - Journal of Molecular …, 2005 - Wiley Online Library
Regulation, recognition and cell signaling involve the coordinated actions of many players.
To achieve this coordination, each participant must have a valid identification (ID) that is …

Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding

M Thali, JP Moore, C Furman, M Charles… - Journal of …, 1993 - Am Soc Microbiol
Interaction with the CD4 receptor enhances the exposure on the human immunodeficiency
type 1 gp120 exterior envelope glycoprotein of conserved, conformation-dependent …

Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity

M Veillette, A Désormeaux, H Medjahed… - Journal of …, 2014 - Am Soc Microbiol
ABSTRACT Anti-HIV-1 envelope glycoprotein (Env) antibodies without broadly neutralizing
activity correlated with protection in the RV144 clinical trial, stimulating interest in other …