Introduction: Inositol and its derivatives comprise a huge field of biology. Myo-inositol is not
only a prominent component of membrane-incorporated phosphatidylinositol, but …

Tyr phosphatases are, by definition, enzymes that dephosphorylate phospho‐Tyr (pT yr)
from proteins. This activity is found in several structurally diverse protein families, including …

Synthesis of phosphatidylinositol-3-phosphate (PI3P) by Vps34, a class III
phosphatidylinositol 3-kinase (PI3K), is critical for the initial steps of autophagosome (AP) …

Appropriate axonal growth and connectivity are essential for functional wiring of the brain.
Joubert syndrome-related disorders (JSRD), a group of ciliopathies in which mutations …

Despite their low abundance, phosphoinositides play a central role in membrane traffic and
signalling. PtdIns (3, 4, 5) P3 and PtdIns (3, 4) P2 are uniquely important, as they promote …

There are eight members of the phosphoinositide family of phospholipids in eukaryotes; PI,
PI3P, PI4P, PI5P, PI (4, 5) P 2, PI (3, 4) P 2, PI (3, 5) P 2 and PI (3, 4, 5) P 3. Receptor …

Primary cilia are solitary signalling organelles projecting from the surface of most cell types.
Although the ciliary membrane is continuous with the plasma membrane it exhibits a unique …

Abstract Background Prohibitin 2 (PHB2) exhibits opposite functions of promoting or
inhibiting tumour across various cancer types. In this study, we aim to investigate its …

A subset of genetic disorders termed ciliopathies are associated with obesity. The
mechanisms behind cilia dysfunction and altered energy homeostasis in these syndromes …

How cytotoxic T lymphocytes (CTLs) sense T cell receptor (TCR) signaling in order to
specialize an area of plasma membrane for granule secretion is not understood. Here, we …