The state of complement in COVID-19

B Afzali, M Noris, BN Lambrecht… - Nature Reviews …, 2022 - nature.com
Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …

Long COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint …

M Gyöngyösi, P Alcaide, FW Asselbergs… - Cardiovascular …, 2023 - academic.oup.com
Long COVID has become a world-wide, non-communicable epidemic, caused by long-
lasting multiorgan symptoms that endure for weeks or months after SARS-CoV-2 infection …

[HTML][HTML] TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

L Hoste, L Roels, L Naesens, V Bosteels… - Journal of Experimental …, 2022 - rupress.org
In rare instances, pediatric SARS-CoV-2 infection results in a novel immunodysregulation
syndrome termed multisystem inflammatory syndrome in children (MIS-C). We compared …

[HTML][HTML] Complement and COVID-19: Three years on, what we know, what we don't know, and what we ought to know

WM Zelek, RA Harrison - Immunobiology, 2023 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus was identified in
China in 2019 as the causative agent of COVID-19, and quickly spread throughout the …

Longitudinal outcomes and monitoring of patients with multisystem inflammatory syndrome in children

MA Fremed, KM Farooqi - Frontiers in Pediatrics, 2022 - frontiersin.org
The acute manifestations and short-term outcomes of multisystem inflammatory syndrome
(MIS-C) have been extensively described; however, our understanding of the longitudinal …

Targeting arginine in COVID-19-induced immunopathology and vasculopathy

W Durante - Metabolites, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) represents a major public health crisis that has
caused the death of nearly six million people worldwide. Emerging data have identified a …

Innate immune dysregulation in multisystem inflammatory syndrome in children (MIS-C)

J Isaza-Correa, L Ryan, L Kelly, J Allen, A Melo… - Scientific Reports, 2023 - nature.com
MIS-C is a systemic inflammation disorder with poorly characterised immunopathological
mechanisms. We compared changes in the systemic immune response in children with MIS …

Evidence, detailed characterization and clinical context of complement activation in acute multisystem inflammatory syndrome in children

G Sinkovits, J Schnur, L Hurler, P Kiszel… - Scientific Reports, 2022 - nature.com
Multisystem inflammatory syndrome in children (MIS-C) is a rare, life-threatening
complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

Unique cellular immune signatures of multisystem inflammatory syndrome in children

A Rajamanickam, PK Nathella, A Venkataraman… - Plos …, 2022 - journals.plos.org
The clinical presentation of MIS-C overlaps with other infectious/non-infectious diseases
such as acute COVID-19, Kawasaki disease, acute dengue, enteric fever, and systemic …

[HTML][HTML] SARS-CoV-2-specific T cell responses are stronger in children with multisystem inflammatory syndrome compared to children with uncomplicated SARS-CoV …

SR Conway, CA Lazarski, NE Field… - Frontiers in …, 2022 - frontiersin.org
Background Despite similar rates of infection, adults and children have markedly different
morbidity and mortality related to severe acute respiratory syndrome coronavirus-2 (SARS …