Hispanics are the largest racial/ethnic minority group in the United States, and they
experience a substantial burden of kidney disease. Although the prevalence of chronic …

The identification of genetic factors associated with kidney disease has the potential to
provide critical insights into disease mechanisms. Genome-wide association studies have …

Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with
higher risk of kidney disease progression and cardiovascular events, but underlying …

Local ancestry is the source ancestry at each point in the genome of an admixed individual.
Inferred local ancestry is used for admixture mapping and population genetic analyses. We …

OBJECTIVES: The Pancreatitis Activity Scoring System (PASS) has been derived by an
international group of experts via a modified Delphi process. Our aim was to perform an …

Background Metabolic pathways are related to physiological functions and disease states
and are influenced by genetic variation and environmental factors. Hispanics/Latino …

Admixture mapping studies have become more common in recent years, due in part to
technological advances and growing international efforts to increase the diversity of genetic …

Background Genetic studies have primarily been conducted in European ancestry
populations, identifying dozens of loci associated with late-onset Alzheimer's disease (AD) …

Admixture mapping can be used to detect genetic association regions in admixed
populations, such as Hispanics/Latinos, by estimating associations between local ancestry …

Background Genetic factors that influence kidney traits have been understudied for low
frequency and ancestry-specific variants. Methods We combined whole genome sequencing …