Molecular mechanisms of viral oncogenesis in humans

NA Krump, J You - Nature Reviews Microbiology, 2018 - nature.com
Viral infection is a major contributor to the global cancer burden. Recent advances have
revealed that seven known oncogenic viruses promote tumorigenesis through shared host …

Adult T-cell leukemia: molecular basis for clonal expansion and transformation of HTLV-1–infected T cells

T Watanabe - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell
leukemia virus type 1 (HTLV-1) that develops through a multistep carcinogenesis process …

Peripheral T cell lymphomas: from the bench to the clinic

D Fiore, LV Cappelli, A Broccoli, PL Zinzani… - Nature Reviews …, 2020 - nature.com
Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of orphan neoplasms.
Despite the introduction of anthracycline-based chemotherapy protocols, with or without …

Human T cell leukemia virus type 1: persistence and pathogenesis

CRM Bangham - Annual review of immunology, 2018 - annualreviews.org
Human T cell leukemia virus type 1 (HTLV-1), also known as human T lymphotropic virus
type 1, was the first exogenous human retrovirus discovered. Unlike the distantly related …

HTLV-1 bZIP factor: the key viral gene for pathogenesis

M Matsuoka, JM Mesnard - Retrovirology, 2020 - Springer
Human T cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL)
and inflammatory diseases. The HTLV-1 bZIP factor (HBZ) gene is constantly expressed in …

Aggressive T‐cell lymphomas: 2019 updates on diagnosis, risk stratification, and management

JM Zain - American journal of hematology, 2019 - Wiley Online Library
Introduction Aggressive T‐cell lymphomas continue to have a poor prognosis. There are
over 27 different subtypes of peripheral T‐cell lymphoma (PTCL) and we are now beginning …

Aggressive T‐cell lymphomas: 2021 Updates on diagnosis, risk stratification and management

JM Zain, P Hanona - American Journal of Hematology, 2021 - Wiley Online Library
Introduction Aggressive T‐cell lymphomas continue to have a poor prognosis. There are
over 27 different subtypes of peripheral T‐cell lymphoma (PTCL), and we are now beginning …

Orchestration of protein acetylation as a toggle for cellular defense and virus replication

LA Murray, X Sheng, IM Cristea - Nature communications, 2018 - nature.com
Emerging evidence highlights protein acetylation, a prevalent lysine posttranslational
modification, as a regulatory mechanism and promising therapeutic target in human viral …

HTLV deregulation of the NF-κB pathway: An update on tax and antisense proteins role

S Fochi, S Mutascio, U Bertazzoni, D Zipeto… - Frontiers in …, 2018 - frontiersin.org
Human T-cell lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell
leukemia (ATL), an aggressive CD4+/CD25+ T-cell malignancy and of a severe …

Viral, genetic, and immune factors in the oncogenesis of adult T-cell leukemia/lymphoma

J Yasunaga - International Journal of Hematology, 2023 - Springer
Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature CD4+ T cells induced by
human T-cell leukemia virus type I (HTLV-1). HTLV-1 maintains life-long infection in the …