Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …

The four distinct T-cell antigen receptor polypeptides (α, β, γ, δ) form two different
heterodimers (α: β and γ: δ) that are very similar to immunoglobulins in primary sequence …

The class I histocompatibility antigen from human cell membranes has two structural motifs:
the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin …

Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are
clustered on top of the molecule in a large groove identified as the recognition site for …

MHC class II molecules assemble in the endoplasmic reticulum in a chaperone-mediated
fashion to form a nine-chain structure consisting of three alpha beta dimers associated with …

To understand the effect of human MHC class II polymorphism on antigen recognition, we
analyzed the memory T cell response to three tetanus toxin epitopes defined by three short …

Dendritic cells (DCs) have the unique capacity to initiate primary and secondary immune
responses,,. They acquire antigens in peripheral tissues and migrate to lymphoid organs …

Both human and murine cytotoxic T cells (CTL) elicited in response to infection with
influenza A viruses have been shown to be specific for internal viral proteins, such as the …

MHC class II molecules display antigenic peptides on cell surfaces for recognition by CD4
(+) T cells. Proteolysis is required in this process both for degradation of invariant chain (Ii) …

The primary structure of T cell receptor proteins and genes is well understood.
Immunologists are now trying to understand the properties of these interesting molecules …